Translations:Sulbutiamine/9/en: Difference between revisions

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Message definition (Sulbutiamine)
==History==
[[File:Thiamin.svg|left|thumb|200px|Thiamine]]
Efforts to develop [[thiamine]] derivatives with better bioavailability than thiamine were conducted in the 1950s, mainly in Japan.  These efforts led to the discovery of [[allicin]] (diallyl [[thiosulfinate]]) in garlic, which became a model for [[medicinal chemistry]] efforts to create other thiamine disulfides.  The results included sulbutiamine, [[fursultiamine]] (thiamine tetrahydrofurfuryl disulfide) and [[benfotiamine]].  These compounds are hydrophobic, easily pass from the intestines to the bloodstream, and are reduced to thiamine by cysteine or glutathione.

History

Thiamine

Efforts to develop thiamine derivatives with better bioavailability than thiamine were conducted in the 1950s, mainly in Japan. These efforts led to the discovery of allicin (diallyl thiosulfinate) in garlic, which became a model for medicinal chemistry efforts to create other thiamine disulfides. The results included sulbutiamine, fursultiamine (thiamine tetrahydrofurfuryl disulfide) and benfotiamine. These compounds are hydrophobic, easily pass from the intestines to the bloodstream, and are reduced to thiamine by cysteine or glutathione.

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