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Fursultiamine/ja: Difference between revisions

Fursultiamine/ja
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<languages />
<languages />
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{{Short description|Chemical compound}}
{{Drugbox
{{Drugbox
| IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
| IUPAC_name = ''N''-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-''N''-<nowiki>{</nowiki>(1''E'')-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
| image = Fursultiamine.png
| image = Fursultiamine.png
| alt = Skeletal formula of fursultiamine
| alt = フルスルチアミンの骨格式
| width = 200
| width = 200
| image2 = Fursultiamine 3D ball.png
| image2 = Fursultiamine 3D ball.png
| alt2 = Ball-and-stick model of the fursultiamine molecule
| alt2 = フルスルチアミン分子のボール＆スティックモデル
| width2 = 200
| width2 = 200
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<!--Clinical data-->
<!--Clinical data-->
| tradename =   
| tradename =   
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| legal_status = otc
| legal_status = otc
| routes_of_administration = [[Mouth|Oral]]
| routes_of_administration = [[Mouth|Oral]]
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<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability =   
| bioavailability =   
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| elimination_half-life =   
| elimination_half-life =   
| excretion =
| excretion =
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<!--Identifiers-->
<!--Identifiers-->
| CAS_number = 804-30-8
| CAS_number = 804-30-8
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| UNII_Ref = {{fdacite|correct|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 05J61265PX
| UNII = 05J61265PX
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<!--Chemical data-->
<!--Chemical data-->
| C=17 | H=26 | N=4 | O=3 | S=2  
| C=17 | H=26 | N=4 | O=3 | S=2  
| smiles = O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C
| smiles = O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C
}}
}}
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'''フルスルチアミン'''（[[:en:International Nonproprietary Name|INN]]、化学名'''チアミンテトラヒドロフルフリルジスルフィド'''または'''TTFD'''； 商品名'''Adventan'''、'''Alinamin-F'''、'''Benlipoid'''、'''Bevitol Lipophil'''、'''Judolor'''、'''Lipothiamine'''）は、[[thiamine/ja|チアミン]]欠乏症の治療に用いられる医薬品およびビタミン剤である。 化学的には[[disulfide/ja|ジスルフィド]]である。化学的にはチアミンの[[derivative (chemistry)/ja|誘導体]]であり、[[allithiamine/ja|アリチアミン]]と構造が似ている。
'''Fursultiamine''' ([[International Nonproprietary Name|INN]]; chemical name '''thiamine tetrahydrofurfuryl disulfide''' or '''TTFD'''; brand names '''Adventan''', '''Alinamin-F''', '''Benlipoid''', '''Bevitol Lipophil''', '''Judolor''', '''Lipothiamine''') is a medication and vitamin used to treat [[thiamine]] deficiency.  Chemically, it is a [[disulfide]] [[derivative (chemistry)|derivative]] of thiamine and is similar in structure to [[allithiamine]].
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1960年代に[[:ja:日本|日本]]で、[[Thiamine/ja#Deficiency|ビタミンB<sub>1</sub>欠乏症]]（すなわち[[beriberi/ja|脚気]]）の治療用に[[lipophilicity/ja|親油性]]を改善した形態のチアミンを開発する目的で[[allithiamine/ja|アリチアミン]]から合成され、その後日本だけでなく、[[:ja:スペイン|スペイン]]、[[:ja:オーストリア|オーストリア]]、[[:ja:ドイツ|ドイツ]]、[[:ja:アメリカ|アメリカ]]でも商業化された。
It was synthesized in [[Japan]] in the 1960s from [[allithiamine]] for the purpose of developing forms of thiamine with improved [[lipophilicity]] for treating [[Thiamine#Deficiency|vitamin B<sub>1</sub> deficiency]] (i.e., [[beriberi]]), It was subsequently commercialized not only in Japan but also in [[Spain]], [[Austria]], [[Germany]], and the [[United States]].
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== こちらも参照 ==
== See also ==
* [[Vitamin B1 analogue/ja|ビタミンB<sub>1</sub>類似体]]
* [[Vitamin B1 analogue|Vitamin B<sub>1</sub> analogue]]
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== さらに読む ==
== Further reading ==
* {{cite journal | vauthors = Lonsdale D | title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent | journal = Medical Science Monitor | volume = 10 | issue = 9 | pages = RA199–203 | date = September 2004 | pmid = 15328496 | url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}
* {{cite journal | vauthors = Lonsdale D | title = Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent | journal = Medical Science Monitor | volume = 10 | issue = 9 | pages = RA199–203 | date = September 2004 | pmid = 15328496 | url = http://www.medscimonit.com/fulltxt.php?ICID=11763 }}
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{{Vitamins/ja}}
{{Vitamins}}
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{{二次利用|date=6 April 2023}}
[[Category:Formamides]]
[[Category:Formamides]]
[[Category:Organic disulfides]]
[[Category:Organic disulfides]]
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[[Category:Prodrugs]]
[[Category:Prodrugs]]
[[Category:Thiamine]]
[[Category:Thiamine]]
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