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Message definition (Citric acid cycle ) In the citric acid cycle all the intermediates (e.g. ''[[Citric acid|citrate]]'', ''iso-citrate'', ''[[Alpha-Ketoglutaric acid|alpha-ketoglutarate]]'', ''[[Succinic acid|succinate]]'', ''[[Fumaric acid|fumarate]]'', ''[[Malic acid|malate]]'', and ''[[Oxaloacetic acid|oxaloacetate]]'') are regenerated during each turn of the cycle. Adding more of any of these intermediates to the mitochondrion therefore means that that additional amount is retained within the cycle, increasing all the other intermediates as one is converted into the other. Hence the addition of any one of them to the cycle has an anaplerotic effect, and its removal has a cataplerotic effect. These anaplerotic and cataplerotic reactions will, during the course of the cycle, increase or decrease the amount of ''oxaloacetate'' available to combine with ''acetyl-CoA'' to form ''citric acid''. This in turn increases or decreases the rate of [[Adenosine triphosphate|ATP]] production by the mitochondrion, and thus the availability of ATP to the cell.
クエン酸サイクルではすべての中間体（例えば クエン酸塩 イソクエン酸 、α-ケトグルタル酸塩 コハク酸塩 フマル酸塩 リンゴ酸塩 オキサロ酢酸塩 アセチル-CoA と結合してクエン酸 を形成するために利用可能なオキサロ酢酸 の量を増減させる。その結果、ミトコンドリアによるATP 産生速度が増減し、細胞へのATPの供給が増加する。