Translations:Discovery and development of angiotensin receptor blockers/20/en: Difference between revisions

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Message definition (Discovery and development of angiotensin receptor blockers)
Saralasin was developed in the early 1970s and is an octapeptide analogue of Ang II, where the [[amino acids]] [[Aspartic acid|Asp]]<sup>1</sup>, [[Isoleucine|Ile]]<sup>5</sup> and [[Phenylalanine|Phe]]<sup>8</sup> have been replaced with [[Serine|Ser]]<sup>1</sup>, [[Valine|Val]]<sup>5</sup> and [[Alanine|Ala]]<sup>8</sup>, respectively. Saralasin was not orally [[bioavailable]], had short duration of action and showed [[partial agonist]] activity and therefore it was not suitable as a drug.

Saralasin was developed in the early 1970s and is an octapeptide analogue of Ang II, where the amino acids Asp1, Ile5 and Phe8 have been replaced with Ser1, Val5 and Ala8, respectively. Saralasin was not orally bioavailable, had short duration of action and showed partial agonist activity and therefore it was not suitable as a drug.

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