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Translations:Insulin (medication)/17/ja: Difference between revisions
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Created page with "== 原則 == {{Anchor|Principles}}
thumb|理想化された図は、3回の食事を含む1日の間の、ヒトの[[blood sugar/ja|血糖値
(赤)と糖低下ホルモンであるインスリン(青)の変動を示している。さらに、
砂糖
が豊富な食事と
デンプン
が豊富な食事の影響が強調されている。]] {|class="collapsible collapsed" align="right" width="..."
(No difference)
Latest revision as of 15:57, 21 March 2024
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Message definition (
Insulin (medication)
)
== Principles ==
[[File:Suckale08 fig3 glucose insulin day.png|thumb|The idealised diagram shows the fluctuation of [[blood sugar]] (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day containing three meals. In addition, the effect of a [[sucrose|sugar]]-rich versus a [[starch]]-rich meal is highlighted.]]
{|class="collapsible collapsed" align="right" width="400" border="1" bgcolor="powderblue"|
! bgcolor="#BCD2EE" colspan="8" |Amino Acid Sequence of Insulin Preparations
|-
! colspan="8" bgcolor="azure"| Amino Acid Substitutions
|-
! colspan=1 bgcolor="azure" |
! colspan=3 bgcolor="azure" |
A-Chain Position
! colspan=4 bgcolor="azure" |
B-Chain Position
|-
! width="120" bgcolor="azure" | Source<br />Species
! width="70" bgcolor="azure" | A-8
! width="70" bgcolor="azure" | A-10
! width="70" bgcolor="azure" | A-21
! width="70" bgcolor="azure" | B-28
! width="70" bgcolor="azure" | B-29
! width="70" bgcolor="azure" | B-30
! width="70" bgcolor="azure" | B-31<br />B-32
|-
! bgcolor="ivory" | Bovine
! bgcolor="ivory" | Ala
! bgcolor="ivory" | Val
! bgcolor="ivory" | Asn
! bgcolor="ivory" | Pro
! bgcolor="ivory" | Lys
! bgcolor="ivory" | Ala
! bgcolor="ivory" | N/A
|-
! bgcolor="ivory" | Porcine
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="ivory" | Pro
! bgcolor="ivory" | Lys
! bgcolor="ivory" | Ala
! bgcolor="ivory" | N/A
|-
! bgcolor="ivory" | Human
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="ivory" | Pro
! bgcolor="ivory" | Lys
! bgcolor="ivory" | Thr
! bgcolor="ivory" | N/A
|-
! bgcolor="powderblue" | [[Aspart]] (Novolog)
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="powderblue" | Asp
! bgcolor="ivory" | Lys
! bgcolor="ivory" | Thr
! bgcolor="ivory" | N/A
|-
! bgcolor="powderblue" | [[Lispro]] (Humalog)
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="powderblue" | Lys
! bgcolor="powderblue" | Pro
! bgcolor="ivory" | Thr
! bgcolor="ivory" | N/A
|-
! bgcolor="powderblue" | [[Glulisine]] (Apidra)
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="ivory" | Pro
! bgcolor="powderblue" | Glu
! bgcolor="ivory" | Thr
! bgcolor="ivory" | N/A
|- width="400" border="1"
! bgcolor="powderblue" | [[Glargine]] (Lantus)
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ilc
! bgcolor="powderblue" | Gly
! bgcolor="ivory" | Pro
! bgcolor="ivory" | Lys
! bgcolor="ivory" | Thr
! bgcolor="powderblue" | Arg
|-
! bgcolor="powderblue" | [[Detemir]](Levemir)
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="ivory" | Pro
! bgcolor="ivory" | Lys
! bgcolor="powderblue" | N/A
! bgcolor="powderblue" | [[Myristic acid]]
|-
! bgcolor="powderblue" | [[Insulin degludec|Degludec]](Tresiba)
! bgcolor="ivory" | Thr
! bgcolor="ivory" | Ile
! bgcolor="ivory" | Asn
! bgcolor="ivory" | Pro
! bgcolor="ivory" | Lys
! bgcolor="powderblue" | N/A
! bgcolor="powderblue" | [[Hexadecanedioic acid]]
|-
| bgcolor="azure" colspan=8|
{{center|1='''Ala=Alanine Val=Valine Asn=Asparagine Pro=Proline Lys=Lysine Thr=Threonine Ile=Isoleucine Glu=Glutamine Gly=Glycine'''}}
|}
原則
理想化された図は、3回の食事を含む1日の間の、ヒトの
血糖値
(赤)と糖低下ホルモンであるインスリン(青)の変動を示している。さらに、
砂糖
が豊富な食事と
デンプン
が豊富な食事の影響が強調されている。
インスリン製剤のアミノ酸配列
アミノ酸置換
Aチェーンの位置
Bチェーンの位置
ソース
種
A-8
A-10
A-21
B-28
B-29
B-30
B-31
B-32
ウシ
Ala
Val
Asn
Pro
Lys
Ala
N/A
ブタ
Thr
Ile
Asn
Pro
Lys
Ala
N/A
ヒト
Thr
Ile
Asn
Pro
Lys
Thr
N/A
Aspart/ja
(Novolog)
Thr
Ile
Asn
Asp
Lys
Thr
N/A
Lispro/ja
(Humalog)
Thr
Ile
Asn
Lys
Pro
Thr
N/A
Glulisine/ja
(Apidra)
Thr
Ile
Asn
Pro
Glu
Thr
N/A
Glargine/ja
(Lantus)
Thr
Ilc
Gly
Pro
Lys
Thr
Arg
Detemir/ja
(Levemir)
Thr
Ile
Asn
Pro
Lys
N/A
Myristic acid
Degludec
(Tresiba)
Thr
Ile
Asn
Pro
Lys
N/A
Hexadecanedioic acid/ja
Ala=アラニン Val=バリン Asn=アスパラギン Pro=プロリン Lys=リジン Thr=スレオニン Ile=イソロイシン Glu=グルタミン Gly=グリシン
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