Translations:Insulin/13/en: Difference between revisions

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Message definition (Insulin)
[[NeuroD1]], also known as β2, regulates insulin exocytosis in pancreatic [[β cells]] by directly inducing the expression of [[genes]] involved in exocytosis. It is localized in the [[cytosol]], but in response to high [[glucose]] it becomes [[glycosylated]] by [[OGT (gene)|OGT]] and/or [[phosphorylated]] by [[Extracellular signal-regulated kinases|ERK]], which causes translocation to the nucleus. In the nucleus β2 heterodimerizes with [[TCF3|E47]], binds to the E1 element of the insulin promoter and recruits co-activator [[EP300|p300]] which acetylates β2. It is able to interact with other transcription factors as well in activation of the insulin gene.

NeuroD1, also known as β2, regulates insulin exocytosis in pancreatic β cells by directly inducing the expression of genes involved in exocytosis. It is localized in the cytosol, but in response to high glucose it becomes glycosylated by OGT and/or phosphorylated by ERK, which causes translocation to the nucleus. In the nucleus β2 heterodimerizes with E47, binds to the E1 element of the insulin promoter and recruits co-activator p300 which acetylates β2. It is able to interact with other transcription factors as well in activation of the insulin gene.

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