Translations:Insulin/12/en: Difference between revisions

From Azupedia
Jump to navigation Jump to search
VisualWikitext
FuzzyBot (talk | contribs)
15,166 edits
Importing a new version from external source
Tags: Mobile edit Mobile web edit
 
(No difference)

Latest revision as of 16:33, 18 March 2024

Information about message (contribute)
This message has no documentation. If you know where or how this message is used, you can help other translators by adding documentation to this message.
Message definition (Insulin)
During a low-glucose state, [[PDX1]] (pancreatic and duodenal homeobox protein 1) is located in the nuclear periphery as a result of interaction with [[HDAC1]] and [[HDAC2|2]], which results in downregulation of insulin secretion. An increase in blood [[glucose]] levels causes [[phosphorylation]] of [[PDX1]], which leads it to undergo nuclear translocation and bind the A3 element within the insulin promoter. Upon translocation it interacts with coactivators [[EP300|HAT p300]] and [[SETD7]]. [[PDX1]] affects the [[histone]] modifications through [[acetylation]] and deacetylation as well as [[methylation]]. It is also said to suppress [[glucagon]].

During a low-glucose state, PDX1 (pancreatic and duodenal homeobox protein 1) is located in the nuclear periphery as a result of interaction with HDAC1 and 2, which results in downregulation of insulin secretion. An increase in blood glucose levels causes phosphorylation of PDX1, which leads it to undergo nuclear translocation and bind the A3 element within the insulin promoter. Upon translocation it interacts with coactivators HAT p300 and SETD7. PDX1 affects the histone modifications through acetylation and deacetylation as well as methylation. It is also said to suppress glucagon.

Retrieved from "https://wiki.tiffa.net/w/index.php?title=Translations:Insulin/12/en&oldid=129866"