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Message definition (Cytochrome P450 ) ====Steroid hormones====
Steroid hormones Steroidogenesis , showing many of the enzyme activities that are performed by cytochrome P450 enzymes. HSD: Hydroxysteroid dehydrogenase.A subset of cytochrome P450 enzymes play important roles in the synthesis of steroid hormones (steroidogenesis ) by the adrenals , gonads , and peripheral tissue:
CYP11A1 (also known as P450scc or P450c11a1) in adrenal mitochondria affects "the activity formerly known as 20,22-desmolase" (steroid 20α-hydroxylase, steroid 22-hydroxylase, cholesterol side-chain scission).CYP11B1 (encoding the protein P450c11β) found in the inner mitochondrial membrane of adrenal cortex has steroid 11β-hydroxylase, steroid 18-hydroxylase , and steroid 18-methyloxidase activities.CYP11B2 (encoding the protein P450c11AS), found only in the mitochondria of the adrenal zona glomerulosa , has steroid 11β-hydroxylase, steroid 18-hydroxylase, and steroid 18-methyloxidase activities.CYP17A1 , in endoplasmic reticulum of adrenal cortex has steroid 17α-hydroxylase and 17,20-lyase activities.CYP21A2 (P450c21) in adrenal cortex conducts 21-hydroxylase activity.CYP19A (P450arom, aromatase ) in endoplasmic reticulum of gonads , brain , adipose tissue , and elsewhere catalyzes aromatization of androgens to estrogens .