Translations:Cytochrome P450/24/en: Difference between revisions

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Message definition (Cytochrome P450)
====Interaction of other substances====
Naturally occurring compounds may also induce or inhibit P450 activity. For example, [[Bioactive compound|bioactive]] compounds found in [[grapefruit juice]] and some other fruit juices, including [[bergamottin]], [[dihydroxybergamottin]], and [[paradicin-A]], have been found to inhibit CYP3A4-mediated metabolism of [[Grapefruit–drug interactions|certain medications]], leading to increased [[bioavailability]] and, thus, the strong possibility of [[overdosing]]. Because of this risk, avoiding grapefruit juice and fresh grapefruits entirely while on drugs is usually advised.

Interaction of other substances

Naturally occurring compounds may also induce or inhibit P450 activity. For example, bioactive compounds found in grapefruit juice and some other fruit juices, including bergamottin, dihydroxybergamottin, and paradicin-A, have been found to inhibit CYP3A4-mediated metabolism of certain medications, leading to increased bioavailability and, thus, the strong possibility of overdosing. Because of this risk, avoiding grapefruit juice and fresh grapefruits entirely while on drugs is usually advised.

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