Translations:Metformin/46/en: Difference between revisions

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Message definition (Metformin)
=== Pharmacokinetics ===
Metformin has an oral [[bioavailability]] of 50–60% under [[fasting]] conditions, and is absorbed slowly. Peak plasma concentrations (C<sub>max</sub>) are reached within 1–3 hours of taking immediate-release metformin and 4–8 hours with extended-release formulations. The [[plasma protein binding]] of metformin is negligible, as reflected by its very high [[volume of distribution|apparent volume of distribution]] (300–1000&nbsp;L after a single dose). [[Steady state]] is usually reached in 1–2 days.

Pharmacokinetics

Metformin has an oral bioavailability of 50–60% under fasting conditions, and is absorbed slowly. Peak plasma concentrations (Cmax) are reached within 1–3 hours of taking immediate-release metformin and 4–8 hours with extended-release formulations. The plasma protein binding of metformin is negligible, as reflected by its very high apparent volume of distribution (300–1000 L after a single dose). Steady state is usually reached in 1–2 days.

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