Translations:Metformin/38/en: Difference between revisions

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Message definition (Metformin)
=== Mechanism of action ===
The molecular mechanism of metformin is not completely understood. Multiple potential mechanisms of action have been proposed: inhibition of the mitochondrial respiratory chain ([[Respiratory complex I|complex I]]), activation of [[AMP-activated protein kinase]] (AMPK), inhibition of glucagon-induced elevation of [[cyclic adenosine monophosphate]] (cAMP) with reduced activation of [[protein kinase A]] (PKA), complex IV–mediated inhibition of the GPD2 variant of mitochondrial [[Glycerol-3-phosphate dehydrogenase#GPD2|glycerol-3-phosphate dehydrogenase]] (thereby reducing glycerol-derived hepatic gluconeogenesis), and an effect on [[gut flora|gut microbiota]].

Mechanism of action

The molecular mechanism of metformin is not completely understood. Multiple potential mechanisms of action have been proposed: inhibition of the mitochondrial respiratory chain (complex I), activation of AMP-activated protein kinase (AMPK), inhibition of glucagon-induced elevation of cyclic adenosine monophosphate (cAMP) with reduced activation of protein kinase A (PKA), complex IV–mediated inhibition of the GPD2 variant of mitochondrial glycerol-3-phosphate dehydrogenase (thereby reducing glycerol-derived hepatic gluconeogenesis), and an effect on gut microbiota.

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