Translations:Atherosclerosis/70/en: Difference between revisions

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Message definition (Atherosclerosis)
== Research ==
===Lipids===
An indication of the role of [[high-density lipoprotein]] (HDL) on atherosclerosis has been with the rare [[ApoA-1 Milano|Apo-A1 Milano]] human genetic variant of this [[High-density lipoprotein|HDL]] protein. A small short-term trial using bacterial synthesized human [[ApoA-1 Milano|Apo-A1 Milano]] HDL in people with unstable angina produced a fairly dramatic reduction in measured coronary plaque volume in only six weeks vs. the usual increase in plaque volume in those randomized to placebo. The trial was published in ''[[JAMA]]'' in early 2006.  Ongoing work starting in the 1990s may lead to human clinical trials—probably by about 2008. These may use synthesized Apo-A1 Milano HDL directly, or they may use gene-transfer methods to pass the ability to synthesize the Apo-A1 Milano HDLipoprotein.

Research

Lipids

An indication of the role of high-density lipoprotein (HDL) on atherosclerosis has been with the rare Apo-A1 Milano human genetic variant of this HDL protein. A small short-term trial using bacterial synthesized human Apo-A1 Milano HDL in people with unstable angina produced a fairly dramatic reduction in measured coronary plaque volume in only six weeks vs. the usual increase in plaque volume in those randomized to placebo. The trial was published in JAMA in early 2006. Ongoing work starting in the 1990s may lead to human clinical trials—probably by about 2008. These may use synthesized Apo-A1 Milano HDL directly, or they may use gene-transfer methods to pass the ability to synthesize the Apo-A1 Milano HDLipoprotein.

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