Created page with "14歳以上の10代と成人に対する現在のAIは、5 mg/日である。これは、典型的な食事の場合、尿中排泄量は約2.6 mg/日であり、食物結合パントテン酸の生物学的利用能はおよそ50％であるという観察に基づいている。妊娠中のAIは6 mg/日である。授乳期のAIは7 mg/日である。12ヵ月までの乳児のAIは1.8 mg/日である。1..."
Created page with "パントテン酸の必須性は、1933年にロジャー・J・ウィリアムズによって酵母の成長に必要であることを示すことによって発見された。その3年後、ElvehjemとJukesは、それがニワトリの成長と抗皮膚炎因子であることを証明した。ウィリアムズはこの化合物を「パントテン酸」と命名し、ギリシャ語の「パントテン（pantothen）」に由来する..."
While for many nutrients, the US Department of Agriculture uses food composition data combined with food consumption survey results to estimate average consumption, the surveys and reports do not include pantothenic acid in the analyses. Less formal estimates of adult daily intakes report about 4 to 7 mg/day.
The [[European Food Safety Authority]] (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined the same as in the US. For women and men over age 11 the Adequate Intake (AI) is set at 5 mg/day. AI for pregnancy is 5 mg/day, for lactation 7 mg/day. For children ages 1–10 years the AI is 4 mg/day. These AIs are similar to the US AIs.
As for safety, the IOM sets [[Tolerable upper intake level]]s (ULs) for vitamins and minerals when evidence is sufficient. In the case of pantothenic acid there is no UL, as there is no human data for adverse effects from high doses. The EFSA also reviewed the safety question and reached the same conclusion as in United States – that there was not sufficient evidence to set a UL for pantothenic acid.
For US food and dietary supplement labeling purposes the amount in a serving is expressed as a percent of Daily Value (%DV). For pantothenic acid labeling purposes 100% of the Daily Value was 10 mg, but as of 27 May 2016 it was revised to 5 mg to bring it into agreement with the AI.
Compliance with the updated labeling regulations was required by 1 January 2020 for manufacturers with [[US$]]10 million or more in annual food sales, and by 1 January 2021 for manufacturers with lower volume food sales. A table of the old and new adult daily values is provided at [[Reference Daily Intake]].
Food sources of pantothenic acid include animal-sourced foods, including dairy foods and eggs. Potatoes, tomato products, oat-cereals, sunflower seeds, avocado are good plant sources. Mushrooms are good sources, too. Whole grains are another source of the vitamin, but milling to make white rice or white flour removes much of the pantothenic acid, as it is found in the outer layers of whole grains. In animal feeds, the most important sources are alfalfa, cereal, fish meal, peanut meal, molasses, rice bran, wheat bran, and yeasts.
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===サプリメント===
===Supplements===
パントテン酸の[[Dietary supplements/ja|栄養補助食品]]は、一般的に[[pantothenol/ja|パントフェノール]]（または''パンテノール''）を使用する。[[Shelf-stable food/ja|常温可能な可能な]][[Functional analog (chemistry)/ja|アナログ]]を使用するのが一般的であり、消費されるとパントテン酸に変換される。パントテン酸カルシウムは、酸、[[alkali/ja|アルカリ]]、熱などの安定性を悪化させる要因に対してパントテン酸よりも耐性があるため、製造に使用されることがある。栄養補助食品に含まれるパントテン酸の量は、最大1,000 mg（成人の必要摂取量の200倍）まで含まれることがあるが、そのような多量摂取が有益であるという証拠はない。[[:en:WebMD|WebMD]]によると、パントテン酸サプリメントには主張されている用途の長いリストがあるが、そのいずれをも支持する科学的証拠は不十分である。
[[Dietary supplements]] of pantothenic acid commonly use [[pantothenol]] (or ''panthenol''), a [[Shelf-stable food|shelf-stable]] [[Functional analog (chemistry)|analog]], which is converted to pantothenic acid once consumed. Calcium pantothenate – a [[salt (chemistry)|salt]] – may be used in manufacturing because it is more resistant than pantothenic acid to factors that deteriorate stability, such as acid, [[alkali]] or heat. The amount of pantothenic acid in dietary supplement products may contain up to 1,000 mg (200 times the Adequate Intake level for adults), without evidence that such large amounts provide any benefit. According to [[WebMD]], pantothenic acid supplements have a long list of claimed uses, but there is insufficient scientific evidence to support any of them.
As a dietary supplement, pantothenic acid is not the same as [[pantethine]], which is composed of two pantothenic acid molecules linked by a [[disulfide]] bridge. Sold as a high-dose supplement (600 mg), pantethine may be effective for lowering blood levels of [[LDL cholesterol]] – a [[risk factor]] for cardiovascular diseases – but its long-term effects are unknown, requiring that its use be supervised by a physician. Dietary supplementation with pantothenic acid does not have the same effect on LDL.
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===強化===
===Fortification===
Global Fortification Data Exchangeによると、パントテン酸の欠乏は非常にまれであるため、食品を強化することを義務付けている国はない。
According to the Global Fortification Data Exchange, pantothenic acid deficiency is so rare that no countries require that foods be fortified.
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==吸収、代謝および排泄==
==Absorption, metabolism and excretion==
{{Anchor|Absorption, metabolism and excretion}}
When found in foods, most pantothenic acid is in the form of CoA or bound to [[acyl carrier protein]] (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the [[Lumen (anatomy)|lumen]] of the intestine, CoA and ACP are [[Hydrolysis|hydrolyzed]] into 4'-phosphopantetheine. The 4'-phosphopantetheine is then [[Dephosphorylation|dephosphorylated]] into [[pantetheine]]. [[Pantetheine hydrolase|Pantetheinase]], an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid. Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system. At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be additionally absorbed via passive diffusion. As a whole, when intake increases 10-fold, absorption rate decreases to 10%.
Pantothenic acid is excreted in urine. This occurs after its release from CoA. Urinary amounts are on the order of 2.6 mg/day, but decreased to negligible amounts when subjects in multi-week experimental situations were fed diets devoid of the vitamin.
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==欠乏症==
==Deficiency==
{{Anchor|Deficiency}}
Pantothenic acid deficiency in humans is very rare and has not been thoroughly studied. In the few cases where deficiency has been seen (prisoners of war during World War II, victims of starvation, or limited volunteer trials), nearly all symptoms were reversed with orally administered pantothenic acid. Symptoms of deficiency are similar to other [[vitamin B]] deficiencies. There is impaired energy production, due to low CoA levels, which could cause symptoms of irritability, [[Fatigue (medical)|fatigue]], and [[apathy]]. Acetylcholine synthesis is also impaired; therefore, neurological symptoms can also appear in deficiency; they include sensation of numbness in hands and feet, [[paresthesia]] and muscle cramps. Additional symptoms could include restlessness, malaise, sleep disturbances, nausea, vomiting and abdominal cramps.
In animals, symptoms include disorders of the nervous, gastrointestinal, and immune systems, reduced growth rate, decreased food intake, skin lesions and changes in hair coat, and alterations in lipid and carbohydrate metabolism. In rodents, there can be loss of hair color, which led to marketing of pantothenic acid as a dietary supplement which could prevent or treat graying of hair in humans (despite the lack of any human trial evidence).
Pantothenic acid status can be assessed by measuring either whole blood concentration or 24-hour urinary excretion. In humans, whole blood values less than 1 μmol/L are considered low, as is urinary excretion of less than 4.56 mmol/day.
Calcium pantothenate and dexpanthenol (D-panthenol) are European Food Safety Authority (EFSA) approved additives to animal feed. Supplementation is on the order of 8–20 mg/kg for pigs, 10–15 mg/kg for poultry, 30–50 mg/kg for fish and 8–14 mg/kg feed for pets. These are recommended concentrations, designed to be higher than what are thought to be requirements. There is some evidence that feed supplementation increases pantothenic acid concentration in tissues, i.e., meat, consumed by humans, and also for eggs, but this raises no concerns for consumer safety.
No dietary requirement for pantothenic acid has been established in ruminant species. Synthesis of pantothenic acid by [[Rumen|ruminal]] microorganisms appears to be 20 to 30 times more than dietary amounts. Net microbial synthesis of pantothenic acid in the rumen of steer calves has been estimated to be 2.2 mg/kg of digestible organic matter consumed per day. Supplementation of pantothenic acid at 5 to 10 times theoretical requirements did not improve growth performance of feedlot cattle.
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==合成==
==Synthesis==
{{Anchor|Synthesis}}
===Biosynthesis===
===生合成===
Bacteria synthesize pantothenic acid from the amino acids aspartate and a precursor to the amino acid valine. Aspartate is converted to [[β-alanine]]. The amino group of valine is replaced by a keto-[[Moiety (chemistry)|moiety]] to yield [[α-ketoisovalerate]], which, in turn, forms α-ketopantoate following transfer of a methyl group, then D-pantoate (also known as pantoic acid) following reduction. β-alanine and pantoic acid are then condensed to form pantothenic acid (see figure).
The industrial synthesis of pantothenic acid starts with the [[aldol condensation]] of [[isobutyraldehyde]] and [[formaldehyde]]. The resulting [[hydroxypivaldehyde]] is converted to its [[cyanohydrin]] derivative. which is cyclised to give [[racemic]] pantolactone. This sequence of reactions was first published in 1904.
Synthesis of the vitamin is completed by [[Chiral resolution|resolution]] of the lactone using [[quinine]], for example, followed by treatment with the calcium or sodium salt of β-alanine.
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==歴史==
==History==
{{Anchor|History}}
{{Further|Vitamin#History}}
{{Further/ja|Vitamin/ja#History}}
The term ''vitamin'' is derived from the word ''vitamine'', which was coined in 1912 by Polish biochemist [[Casimir Funk]], who isolated a complex of water-soluble micronutrients essential to life, all of which he presumed to be [[amine]]s. When this presumption was later determined not to be true, the "e" was dropped from the name, hence "vitamin". Vitamin nomenclature was alphabetical, with [[Elmer McCollum]] calling these fat-soluble A and water-soluble B. Over time, eight chemically distinct, water-soluble B vitamins were isolated and numbered, with pantothenic acid as vitamin B<sub>5</sub>.
パントテン酸の必須性は、1933年に[[:en:Roger J. Williams|ロジャー・J・ウィリアムズ]]によって酵母の成長に必要であることを示すことによって発見された。その3年後、ElvehjemとJukesは、それがニワトリの成長と抗皮膚炎因子であることを証明した。ウィリアムズはこの化合物を「パントテン酸」と命名し、ギリシャ語の「パントテン（pantothen）」に由来する。その理由は、パントテン酸がほとんどすべての食品に含まれていることを発見したからである。ウィリアムズは1940年に化学構造を決定した。1953年、[[:en:Fritz Lipmann|フリッツ・リップマン]]は[[:en:Nobel Prize in Physiology or Medicine|ノーベル生理学・医学賞]]を共有した。1946年に発表した「コエンザイムAとその中間代謝における重要性の発見」に対してである。
The essential nature of pantothenic acid was discovered by [[Roger J. Williams]] in 1933 by showing it was required for the growth of yeast. Three years later Elvehjem and Jukes demonstrated that it was a growth and anti-dermatitis factor in chickens. Williams dubbed the compound "pantothenic acid", deriving the name from the Greek word ''pantothen'', which translates as "from everywhere". His reason was that he found it to be present in almost every food he tested. Williams went on to determine the chemical structure in 1940. In 1953, [[Fritz Lipmann]] shared the [[Nobel Prize in Physiology or Medicine]] "for his discovery of co-enzyme A and its importance for intermediary metabolism", work he had published in 1946.
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{{Metabolism of vitamins, coenzymes, and cofactors/ja}}
{{Metabolism of vitamins, coenzymes, and cofactors}}
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