Translations:Pantothenic acid/5/en: Difference between revisions

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Message definition (Pantothenic acid)
==Use in biosynthesis of coenzyme A==
[[File:CoA_Biosynthetic_Pathway.png|thumb|left|Details of the biosynthetic pathway of CoA synthesis from pantothenic acid]]
Pantothenic acid is a precursor to CoA via a five-step process.  The biosynthesis requires pantothenic acid, cysteine, and four equivalents of ATP (see figure).
# Pantothenic acid is [[Phosphorylation|phosphorylated]] to 4′-phosphopantothenate by the enzyme [[pantothenate kinase]]. This is the committed step in CoA biosynthesis and requires ATP.
# A [[cysteine]] is added to 4′-phosphopantothenate by the enzyme [[phosphopantothenoylcysteine synthetase]] to form 4'-phospho-N-pantothenoylcysteine (PPC). This step is coupled with [[ATP hydrolysis]].
# PPC is [[Decarboxylation|decarboxylated]] to [[4'-phosphopantetheine|4′-phosphopantetheine]] by [[phosphopantothenoylcysteine decarboxylase]]
# 4′-Phosphopantetheine is adenylated (or more properly, [[Adenylation|AMPylated]]) to form dephospho-CoA by the enzyme [[Pantetheine-phosphate adenylyltransferase|phosphopantetheine adenylyl transferase]]
# Finally, dephospho-CoA is phosphorylated to coenzyme A by the enzyme [[dephospho-CoA kinase|dephosphocoenzyme A kinase]]. This final step also requires ATP.

Use in biosynthesis of coenzyme A

Details of the biosynthetic pathway of CoA synthesis from pantothenic acid

Pantothenic acid is a precursor to CoA via a five-step process. The biosynthesis requires pantothenic acid, cysteine, and four equivalents of ATP (see figure).

  1. Pantothenic acid is phosphorylated to 4′-phosphopantothenate by the enzyme pantothenate kinase. This is the committed step in CoA biosynthesis and requires ATP.
  2. A cysteine is added to 4′-phosphopantothenate by the enzyme phosphopantothenoylcysteine synthetase to form 4'-phospho-N-pantothenoylcysteine (PPC). This step is coupled with ATP hydrolysis.
  3. PPC is decarboxylated to 4′-phosphopantetheine by phosphopantothenoylcysteine decarboxylase
  4. 4′-Phosphopantetheine is adenylated (or more properly, AMPylated) to form dephospho-CoA by the enzyme phosphopantetheine adenylyl transferase
  5. Finally, dephospho-CoA is phosphorylated to coenzyme A by the enzyme dephosphocoenzyme A kinase. This final step also requires ATP.<
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