Translations:Discovery and development of gliflozins/8/en: Difference between revisions

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Message definition (Discovery and development of gliflozins)
In diabetes, extracellular glucose concentration increases and this high glucose level leads to [[Downregulation and upregulation|upregulation]] of SGLT-2, leading in turn to more absorption of glucose in the kidneys. These effects cause maintenance of [[hyperglycemia]]. Because sodium is absorbed at the same time as glucose via SGLT-2, the upregulation of SGLT-2 probably leads to development or maintenance of [[hypertension]]. In study where rats were given either [[ramipril]] or [[losartan]], levels of SGLT-2 protein and [[mRNA]] were significantly reduced. In patients with diabetes, hypertension is a common problem so this may have relevance in this disease.

In diabetes, extracellular glucose concentration increases and this high glucose level leads to upregulation of SGLT-2, leading in turn to more absorption of glucose in the kidneys. These effects cause maintenance of hyperglycemia. Because sodium is absorbed at the same time as glucose via SGLT-2, the upregulation of SGLT-2 probably leads to development or maintenance of hypertension. In study where rats were given either ramipril or losartan, levels of SGLT-2 protein and mRNA were significantly reduced. In patients with diabetes, hypertension is a common problem so this may have relevance in this disease.

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