Translations:GLP-1 receptor agonist/4/en: Difference between revisions

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Message definition (GLP-1 receptor agonist)
==Mechanism of action==
GLP-1 agonists work by activating the [[GLP-1 receptor]]. They slow [[gastric emptying]], inhibit the release of [[glucagon]], and stimulate [[insulin]] production, therefore reducing hyperglycemia in people with [[type 2 diabetes]]. They also reduce food intake and therefore body weight, making them an effective treatment for obesity. Another class of anti-diabetes drugs, the [[dipeptidyl peptidase-4 inhibitor|DPP-4 inhibitors]], work by reducing the breakdown of endogenous GLP-1, and are generally considered less potent than GLP-1 agonists. Some of the metabolic effects of GLP-1 agonists in rodents are mediated via increased synthesis of fibroblast growth factor 21 ([[FGF21]]). Dual GLP-1/FGF21 receptor agonists have been developed by pharmaceutical companies.

Mechanism of action

GLP-1 agonists work by activating the GLP-1 receptor. They slow gastric emptying, inhibit the release of glucagon, and stimulate insulin production, therefore reducing hyperglycemia in people with type 2 diabetes. They also reduce food intake and therefore body weight, making them an effective treatment for obesity. Another class of anti-diabetes drugs, the DPP-4 inhibitors, work by reducing the breakdown of endogenous GLP-1, and are generally considered less potent than GLP-1 agonists. Some of the metabolic effects of GLP-1 agonists in rodents are mediated via increased synthesis of fibroblast growth factor 21 (FGF21). Dual GLP-1/FGF21 receptor agonists have been developed by pharmaceutical companies.

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