Translations:Vitamin D/101/en: Difference between revisions

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Message definition (Vitamin D)
=== Difference between substrates ===
Vitamin{{nbsp}}D<sub>2</sub> (ergocalciferol) and vitamin{{nbsp}}D<sub>3</sub> (cholecalciferol) share a similar mechanism of action as outlined above. Metabolites produced by vitamin D<sub>2</sub> are named with an ''er-'' or ''ergo-'' prefix to differentiate them from the D<sub>3</sub>-based counterparts (sometimes with a ''chole-'' prefix).
* Metabolites produced from vitamin{{nbsp}}D<sub>2</sub> tend to bind less well to the vitamin D-binding protein.
* Vitamin{{nbsp}}D<sub>3</sub> can alternatively be hydroxylated to calcifediol by [[sterol 27-hydroxylase]] (CYP27A1), but vitamin{{nbsp}}D<sub>2</sub> cannot.
* Ergocalciferol can be directly hydroxylated at position 24 by [[CYP27A1]]. This hydroxylation also leads to a greater degree of inactivation: the activity of calcitriol decreases to 60% of original after 24-hydroxylation, whereas ercalcitriol undergoes a 10-fold decrease in activity on conversion to ercalcitetrol.

Difference between substrates

Vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) share a similar mechanism of action as outlined above. Metabolites produced by vitamin D2 are named with an er- or ergo- prefix to differentiate them from the D3-based counterparts (sometimes with a chole- prefix).

  • Metabolites produced from vitamin D2 tend to bind less well to the vitamin D-binding protein.
  • Vitamin D3 can alternatively be hydroxylated to calcifediol by sterol 27-hydroxylase (CYP27A1), but vitamin D2 cannot.
  • Ergocalciferol can be directly hydroxylated at position 24 by CYP27A1. This hydroxylation also leads to a greater degree of inactivation: the activity of calcitriol decreases to 60% of original after 24-hydroxylation, whereas ercalcitriol undergoes a 10-fold decrease in activity on conversion to ercalcitetrol.
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