View source for Medical test/ja

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{{Infobox interventions
|  Name        = 医学検査
|  Image       = X-ray by Wilhelm Röntgen of Albert von Kölliker's hand - 18960123-02.jpg
|  Caption     = 手の[[X-ray/ja|X線撮影]]。X線検査は一般的な医学検査である。
|  ICD10       =
|  ICD9        =
|  MeshID      = D019937
|  OtherCodes  =
}}
'''医学検査'''とは、[[screening (medicine)/ja|特定]]、[[medical diagnosis/ja|診断]]、または病気の[[monitoring (medicine)/ja|監視]]、疾病プロセス、感受性、または治療方針を決定するために行われる[[medical procedure/ja|医療処置]]のことである。人間ドックや視力検査、[[diagnostic imaging/ja|画像診断]]、遺伝子検査、[[clinical chemistry/ja|臨床化学]]や[[molecular diagnostics/ja|分子診断学]]に関連する化学・細胞分析などの医学検査は、一般的に[[medical laboratory/ja|医療現場]]で行われる。

==検査の種類 ==
{{Anchor|Types of tests}}

===目的別===
医学検査は、診断、スクリーニング、モニタリングなど、その目的によって分類することができる。

====診断====
[[Image:Lung scintigraphy keosys.JPG|thumb|肺[[scintigraphy/ja|シンチグラフィー]]による肺がんの評価]]
診断検査は、通常、症状の報告後、または他の医学検査結果に基づいて、疾患の疑いがある個人の疾患の存在を確認または決定するために行われる処置である。これには[[posthumous diagnosis/ja|死後診断]]も含まれる。このような検査の例としては、以下のようなものがある：
* [[lymphoma/ja|リンパ腫]]が疑われる患者を[[nuclear medicine/ja|核医学]]で調べる。
* [[diabetes mellitus/ja|糖尿病]]が疑われる人の[[blood sugar/ja|血糖値]]を、[[urination/ja|排尿]]が増加した後に測定する。
* [[bacterial infection/ja|細菌感染]]を調べるために、高[[fever/ja|発熱]]を経験している人の[[complete blood count/ja|全血球数]]を測定する。
* [[chest pain/ja|胸痛]]のある患者の[[electrocardiogram/ja|心電図]]測定値をモニタリングし、[[heart/ja|心臓]]不整脈の診断や判定を行う。

====スクリーニング====
{{Main/ja|Screening (medicine)/ja}}
[[screening (medicine)/ja|スクリーニング]]とは、集団、家族、労働力などの定義されたグループ内のリスクのある個人における疾患の存在を検出または予測するために使用される医学検査または一連の検査のことである。

スクリーニングの例としては、[[congenital hypothyroidism/ja|先天性甲状腺機能低下症]]の[[newborn screening/ja|新生児スクリーニング]]の一環として新生児[[infant/ja|乳児]]の[[blood/ja|血液]]中の[[Thyroid-stimulating hormone/ja|TSH]]のレベルを測定すること、規制されていない労働環境で[[Passive smoke/ja|セコンドハンドスモーク]]にさらされている非喫煙者の[[Lung cancer/ja|肺がん]]をチェックすること、[[cervical cancer/ja|子宮頸がん]]の予防または早期発見のための[[Pap test/ja|パップスメア]]スクリーニングなどがある。

====モニタリング====
{{Main/ja|Monitoring (medicine)/ja}}
いくつかの医学検査は、[[monitoring (medicine)/ja|モニタリング]]の進行状況や[[therapy/ja|医学的治療]]に対する反応を調べるために用いられる。

===方法別===
ほとんどの試験方法は、以下の大まかなグループのいずれかに分類することができる：
* 患者を観察し、写真に撮ったり、記録したりする。
* 個人の[[medical history/ja|病歴]]を調べる際に尋ねられる質問
* [[physical examination/ja|身体検査]]で行われる検査。
* [[Radiologic/ja|放射線]]検査では、例えば[[X-rays/ja|X線]]を使用して身体標的の画像を形成する。これらの検査ではしばしば[[Contrast medium/ja|造影剤]]の投与が行われる。
* 生体内で検査する'''生体内診断'''などがある：
** [[Pressure measurement/ja|マノメトリー]]を行う。
** [[gluten challenge test/ja|グルテン負荷試験]]、[[contraction stress test/ja|収縮負荷試験]]、[[bronchial challenge test/ja|気管支負荷試験]]、[[oral food challenge/ja|経口食物負荷試験]]、[[ACTH stimulation test/ja|ACTH刺激試験]]のように、診断薬を投与し、身体の反応を測定する。
* 組織や体液のサンプルを検査する'''{{Vanchor|In vitro diagnostics}}'''(試験管内診断)などがある：
** [[Circulating tumor cell/ja|液体生検]]
** [[Microbiological culture/ja|微生物学的培養]]、体内サンプル中の微生物の有無を判定するもので、通常は[[pathogenic bacteria/ja|病原性細菌]]の検出を対象とする。
** [[Genetic testing/ja|遺伝学的検査]]
** [[Blood sugar level/ja|血糖値]]
** 肝機能検査
** [[Calcium/ja|カルシウム]]検査
** [[sodium/ja|ナトリウム]]、[[potassium/ja|カリウム]]、[[creatinine/ja|クレアチニン]]、[[urea/ja|尿素]]などの血液中の電解質検査

===検体の部位別===
試験管内検査は、検査される試料の場所によって以下のように分類できる：
* [[blood test/ja|血液検査]]
* [[Urinalysis/ja|尿検査]],肉眼検査を含む
* [[stool test/ja|便検査]],肉眼検査を含む
* [[Sputum/ja|喀痰]]（[[phlegm/ja|痰]]）,肉眼検査を含む

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==Accuracy and precision==
{{Main|Accuracy and precision}}
* '''Accuracy''' of a laboratory test is its correspondence with the true value. Accuracy is maximized by calibrating laboratory equipment with reference material and by participating in external quality control programs.
* '''Precision''' of a test is its reproducibility when it is repeated on the same sample. An imprecise test yields widely varying results on repeated measurement. Precision is monitored in laboratory by using control material.
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==Detection and quantification==
Tests performed in a [[physical examination]] are usually aimed at detecting a [[symptom]] or [[Medical sign|sign]], and in these cases, a test that detects a symptom or sign is designated a [[positive test]], and a test that indicated absence of a symptom or sign is designated a negative test, as further detailed in a separate section below.A quantification of a target substance, a cell type or another specific entity is a common output of, for example, most [[blood test]]s. This is not only answering ''if'' a target entity is present or absent, but also ''how much'' is present. In blood tests, the quantification is relatively well specified, such as given in [[mass concentration (chemistry)|mass concentration]], while most other tests may be quantifications as well although less specified, such as a sign of being "very [[Pallor|pale]]" rather than "slightly pale". Similarly, radiologic images are technically quantifications of radiologic opacity of tissues.
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Especially in the taking of a [[medical history]], there is no clear limit between a detecting or quantifying test versus rather ''descriptive'' information of an individual. For example, questions regarding the occupation or social life of an individual may be regarded as tests that can be regarded as positive or negative for the presence of various risk factors, or they may be regarded as "merely" descriptive, although the latter may be at least as clinically important.
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===Positive or negative===
The result of a test aimed at detection of an entity may be '''positive''' or '''negative''': this has nothing to do with a bad [[prognosis]], but rather means that the test worked or not, and a certain parameter that was evaluated was present or not. For example, a negative [[screening test]] for [[breast cancer]] means that no sign of breast cancer could be found (which is in fact very positive for the patient).
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The classification of tests into either positive or negative gives a [[binary classification]], with resultant ability to perform [[bayesian probability]] and performance metrics of tests, including calculations of [[sensitivity and specificity]].
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===Continuous values===
Tests whose results are of continuous values, such as most [[blood values]], can be interpreted as they are, or they can be [[Artificially binary value|converted to a binary ones]] by defining a [[cutoff (reference value)|cutoff value]], with test results being designated as positive or negative depending on whether the resultant value is higher or lower than the cutoff.
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==Interpretation==
{{Further|Pre- and post-test probability}}
In the finding of a ''[[pathognomonic]]'' sign or symptom it is almost certain that the target condition is present, and in the absence of finding a ''[[sine qua non]]'' sign or symptom it is almost certain that the target condition is absent. In reality, however, the subjective probability of the presence of a condition is never exactly 100% or 0%, so tests are rather aimed at estimating a [[post-test probability]] of a condition or other entity.
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Most diagnostic tests basically use a [[reference group]] to establish performance data such as [[predictive values]], [[likelihood ratios in diagnostic testing|likelihood ratios]] and [[relative risk]]s, which are then used to interpret the post-test probability for an individual.
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In monitoring tests of an individual, the test results from previous tests on that individual may be used as a reference to interpret subsequent tests.
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==Risks==
Some medical testing procedures have associated health risks, and even require [[general anesthesia]], such as the [[mediastinoscopy]]. Other tests, such as the [[blood test]] or [[pap smear]] have little to no direct risks. Medical tests may also have [[Screening (medicine)#Adverse effects of screening|indirect risks]], such as the stress of testing, and riskier tests may be required as follow-up for a (potentially) [[false positive]] test result. Consult the health care provider (including [[physician]]s, [[physician assistant]]s, and [[nurse practitioner]]s) prescribing any test for further information.
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==Indications==
Each test has its own [[Indication (medicine)|indication]]s and contraindications.  An ''indication'' is a valid medical reason to perform the test.  A ''contraindication'' is a valid medical reason not to perform the test.  For example, a basic [[cholesterol test]] may be ''indicated'' (medically appropriate) for a middle-aged person.  However, if the same test was performed on that person very recently, then the existence of the previous test is a contraindication for the test (a medically valid reason to not perform it).
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[[Information bias (psychology)|Information bias]] is the [[cognitive bias]] that causes healthcare providers to order tests that produce information that they do not realistically expect or intend to use for the purpose of making a medical decision.  Medical tests are indicated when the information they produce will be used.  For example, a screening mammogram is not indicated (not medically appropriate) for a woman who is dying, because even if breast cancer is found, she will die before any cancer treatment could begin.
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In a simplified fashion, how much a test is indicated for an individual depends largely on its ''net benefit'' for that individual.  Tests are chosen when the expected benefit is greater than the expected harm.  The net benefit may roughly be estimated by:
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<math> b_n = \Delta p \times r_i \times ( b_i - h_i ) - h_t</math>
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, where:
* ''b<sub>n</sub>'' is the net benefit of performing a test
* ''Λp'' is the absolute difference between [[pre- and posttest probability]] of conditions (such as diseases) that the test is expected to achieve. A major factor for such an absolute difference is the power of the test itself, such as can be described in terms of, for example, [[sensitivity and specificity]] or [[Likelihood ratios in diagnostic testing|likelihood ratio]]. Another factor is the pre-test probability, with a lower pre-test probability resulting in a lower absolute difference, with the consequence that even very powerful tests achieve a low absolute difference for very unlikely conditions in an individual (such as [[rare disease]]s in the absence of any other indicating sign), but on the other hand, that even tests with low power can make a great difference for highly suspected conditions. The probabilities in this sense may also need to be considered in context of conditions that are not primary targets of the test, such as [[Differential diagnosis#profile-relative probability|profile-relative probabilities in a differential diagnostic procedure]].
* ''r<sub>i</sub>'' is the rate of how much ''probability differences'' are expected to result in ''changes in interventions'' (such as a change from "no treatment" to "administration of low-dose medical treatment"). For example, if the only expected effect of a medical test is to make one disease more likely compared to another, but the two diseases have the same treatment (or neither can be treated), then, this factor is very low and the test is probably without value for the individual in this aspect.
* ''b<sub>i</sub>'' is the benefit of ''changes in interventions'' for the individual
* ''h<sub>i</sub>'' is the harm of ''changes in interventions'' for the individual, such as [[side effects]] of medical treatment
* ''h<sub>t</sub>'' is the harm caused by the test itself.
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Some additional factors that influence a decision whether a medical test should be performed or not included: cost of the test, availability of additional tests, potential interference with subsequent test (such as an [[abdominal palpation]] potentially inducing intestinal activity whose sounds interfere with a subsequent [[abdominal auscultation]]), time taken for the test or other practical or administrative aspects. The possible benefits of a diagnostic test may also be weighed against the costs of unnecessary tests and resulting unnecessary follow-up and possibly even unnecessary treatment of incidental findings.
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In some cases, tests being performed are expected to have no benefit for the individual being tested.  Instead, the results may be useful for the establishment of statistics in order to improve health care for other individuals. Patients may give [[informed consent]] to undergo medical tests that will benefit other people.
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==Patient expectations==
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In addition to considerations of the nature of medical testing noted above, other realities can lead to misconceptions and unjustified expectations among patients. These include: Different labs have different normal reference ranges; slightly different values will result from repeating a test; "normal" is defined by a spectrum along a bell curve resulting from the testing of a population, not by "rational, science-based, physiological principles"; sometimes tests are used in the hope of turning something up to give the doctor a clue as to the nature of a given condition; and imaging tests are subject to fallible human interpretation and can show [[Incidental imaging finding|"incidentalomas"]], most of which "are benign, will never cause symptoms, and do not require further evaluation," although clinicians are developing guidelines for deciding when to pursue diagnoses of incidentalomas.
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==報告および評価の基準==
{{Anchor|Standard for the reporting and assessment}}
QUADAS-2リビジョンが発表された。

==医学検査一覧==
{{main/ja|list of medical tests/ja}}

==こちらも参照==
{{col div|colwidth=40em}}
* [[Blood culture/ja]]
* [[Chemical test/ja]]
* [[Gold standard (test)/ja]]
* [[Medical sign/ja]]
* [[Molecular diagnostics/ja]]
* [[Nailbed assessment/ja]]
* [[Test panel/ja]]
* [[Point-of-care testing/ja]]
* [[:en:Regulation (EU) 2017/746|EU IVD Regulation]]
{{colend}}

==さらに読む==
* {{cite book | vauthors = ((World Health Organization)) | title = First WHO Model List of Essential In Vitro Diagnostics | year = 2019 | publisher = World Health Organization | hdl = 10665/311567 | author-link = World Health Organization | location = Geneva | id = WHO Technical Report Series, No. 1017. License: CC BY-NC-SA 3.0 IGO | isbn = 978-92-4-121026-3 | issn = 0512-3054 }}
{{Medical imaging/ja}}
{{Urine tests/ja}}
{{Clinical biochemistry blood tests/ja}}
{{Myeloid blood tests/ja}}
{{CSF tests/ja}}
{{Immunologic techniques and tests/ja}}
{{Transfusion medicine/ja}}
{{Infectious blood tests/ja}}
{{Pathology/ja}}
{{Electrodiagnosis/ja}}
{{Portal bar | Medicine}}

[[Category:Medical tests| ]]
[[Category:Pathology]]