Translations:Vitamin D5/4/en

1α-Hydroxyvitamin D₅ was first synthesized in 1997 by researchers in the Department of Chemistry at the University of Chicago, under Robert M. Moriarty and Dragos Albinescu. By 2005, the group had revised its synthesis method for a more streamlined, higher yield-producing route. It involved the photochemical conversion of precursor 7-dehydrositosteryl acetate to contain a conjugated triene system, a hallmark of this analog, followed by hydroxylation, photoisomerization, and deprotection steps. Their overall yield was 48%.