Translations:Insulin analog/17/en

Research on safety, efficacy, and comparative effectiveness

Main article: Comparative effectiveness research

A meta-analysis completed in 2007 and updated in 2020 of numerous randomized controlled trials by the international Cochrane Collaboration found that the effects on blood glucose and glycated haemoglobin A1c (HbA1c) were comparable, treatment with glargine and detemir resulted in fewer cases of hypoglycemia when compared to NPH insulin. Treatment with detrimir also reduced the frequency of serious hypoglycemia. This review did note limitations, such as low glucose and HbA1c targets, that could limit the applicability of these findings to daily clinical practice.