Translations:Discovery and development of gliflozins/26/en

Many compounds gave different IC₅₀ value in the ring position in an in vitro activity. For an example there was a big difference if there was an n-pentyl group (IC₅₀ = 13,3 nM), n-butyl (IC₅₀ = 119 nM), phenyl with 2-furyl (IC₅₀ = 0,720) or 3-thiophenyl (IC₅₀ = 0,772). As seen in table 1, the in vitro activity increases depending on what compound is bonded to the distal ring (given that in the C-4 region of the proximal phenyl ring is a Cl atom).