Translations:Discovery and development of angiotensin receptor blockers/41/en

All of the ARBs, except for valsartan and olmesartan, are metabolized in some way by the cytochrome P450 (CYP) enzyme 2C9, that is found in the human liver. CYP2C9 is for example responsible for the metabolizing of losartan to EXP 3174 and the slow metabolizing of valsartan and candesartan to their inactive metabolites. Telmisartan is, on the other hand, in part metabolized by glucuronidation and olmesartan is excreted as the unchanged drug. Telmisartan is the only ARB that can cross the blood–brain barrier and can therefore inhibit centrally mediated effects of Ang II, contributing to even better blood pressure control.