Translations:Discovery and development of angiotensin receptor blockers/39/en
Drug comparison and pharmacokinetics
| Drug | Biological half-life [h] | Protein binding [%] | Bioavailability [%] | Renal/hepatic clearance [%] | Food effect | Daily dosage [mg] |
|---|---|---|---|---|---|---|
| Losartan | 2 | 98.7 | 33 | 10/90 | Minimal | 50-100 |
| EXP 3174 | 6-9 | 99.8 | - | 50/50 | - | - |
| Candesartan | 9 | >99 | 15 | 60/40 | No | 4-32 |
| Valsartan | 6 | 95 | 25 | 30/70 | 40-50% decreased by | 80-320 |
| Irbesartan | 11-15 | 90-95 | 70 | 1/99 | No | 150-300 |
| Telmisartan | 24 | >99 | 42-58 | 1/99 | No | 40-80 |
| Eprosartan | 5 | 98 | 13 | 30/70 | No | 400-800 |
| Olmesartan | 14-16 | >99 | 29 | 40/60 | No | 10-40 |
| Sources: | ||||||