Translations:Discovery and development of angiotensin receptor blockers/38/en

Candesartan and olmesartan have the highest affinity for the AT₁ receptors, followed by irbesartan and eprosartan. Valsartan, telmisartan and EXP 3174 have similar affinities that are about ten-fold less than that of candesartan. Losartan has the least affinity. ARBs' affinity for the AT₂ receptor is generally much lower (or around 10,000 times less) than for the AT₁ subtype. Therefore, they allow unhindered stimulation of the AT₂ receptor.