Translations:Diabetic nephropathy/17/en

Staging

To clinically stage the degree of damage in this (and any) kidney disease, the serum creatinine is determined and used to calculate the estimated glomerular filtration rate (eGFR). Normal eGFR is equal to or greater than 90ml/min/1.73 m². On biopsy, the following classification has been suggested by Tervaert et al.:

Histopathologic staging

Class	Description and criteria
I	Mild or nonspecific changes on light microscopy and conformed GBM thickening proven by electron microscopy: GBM > 395 nm (female), GBM > 430 nm (male).
IIa	Mild mesangial expansion in >25% of the observed mesangium. Area of mesangial proliferation < area of capillary cavity.
IIb	Severe mesangial expansion in >25% of the observed mesangium. Area of mesangial proliferation < area of capillary cavity.
III	At least one convincing nodular sclerosis (Kimmelstiel-Wilson lesion).
IV	Advanced diabetic glomerulosclerosis in >50% of glomeruli.