Translations:Cytochrome P450/8/en
The most common reaction catalyzed by cytochromes P450 is a monooxygenase reaction, e.g., insertion of one atom of oxygen into the aliphatic position of an organic substrate (RH), while the other oxygen atom is reduced to water:
RH + O2 + NADPH + H+ → ROH + H2O + NADP+
Many hydroxylation reactions (insertion of hydroxyl groups) use CYP enzymes.