Translations:Angiotensin II receptor blocker/23/en
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Pressor inhibition
Pressor inhibition at trough level — this relates to the degree of blockade or inhibition of the blood pressure-raising ("pressor") effect of angiotensin II. However, pressor inhibition is not a measure of blood pressure-lowering (BP) efficacy per se. The rates as listed in the U.S. Food and Drug Administration (FDA) Package Inserts (PIs) for inhibition of this effect at the 24th hour for the ARBs are as follows:
- Valsartan – 30% at 80 mg
- Telmisartan – 40% at 80 mg
- Losartan – 25–40% at 100 mg
- Irbesartan – 40% at 150 mg; 60% 300 mg
- Azilsartan – 60% at 32 mg
- Olmesartan – 61% at 20 mg; 74% at 40 mg