...cals|フェリング製薬]]は2つのシアノピロリジンDPP-4阻害剤の特許を申請し、1995年に公開した。これらの化合物は優れた[[potency (pharmacology)/ja|効力]]を持ち、化学的安定性も改善されていた。
[[DPP-4 inhibitor/ja|DPP-4阻害剤]]は多様な構造型にまたがっている。2007年には、最も[[potency (pharmacology)/ja|効力]]のある化合物のうち数種類が[[proline/ja|プロリン]][[mimetic/ja|模倣]]シアノピロリジンP1基を含んでいた。
...
41 KB (1,558 words) - 17:16, 12 March 2024
...published in 1995. These compounds had excellent [[potency (pharmacology)|potency]] and improved chemical stability.
...ithout the nitrile group in this research suffered a 20 to 50-fold loss of potency corresponding to the compounds containing the [[nitrile]] group.
...
32 KB (4,417 words) - 10:31, 12 March 2024
...published in 1995. These compounds had excellent [[potency (pharmacology)|potency]] and improved chemical stability.
...ithout the nitrile group in this research suffered a 20 to 50-fold loss of potency corresponding to the compounds containing the [[nitrile]] group.
...
33 KB (4,561 words) - 10:30, 12 March 2024
...a pharmacology")|Materia medica|the journal|Karger Publishers#Journals{{!}}Pharmacology (journal)}}
...Pharmacology and Experimental Therapeutics newsletter|American Society for Pharmacology and Experimental Therapeutics#Publications{{!}}The Pharmacologist}}
...
30 KB (3,998 words) - 20:36, 8 January 2023
...体のグループから弱い非ペプチド性のAng II拮抗薬S-8307とS-8308を発見した。S-8307とS-8308は、中程度の[[Potency (pharmacology)/ja|効力]]、短い作用時間、限られた経口バイオアベイラビリティを持つが、部分作動薬活性を持たない選択的かつ競合的なAT<sub>1</sub>受容
...
27 KB (998 words) - 12:39, 28 March 2024
...acid derivatives. S-8307 and S-8308 have moderate [[Potency (pharmacology)|potency]], short duration of action and limited oral bioavailability, however they
...of the ARBs have the same [[mechanism of action]] and differences in their potency can be related to their different [[pharmacokinetic]] profiles. A few clini
...
22 KB (3,221 words) - 10:25, 28 March 2024
...a pharmacology")|Materia medica|the journal|Karger Publishers#Journals{{!}}Pharmacology (journal)}}
...Pharmacology and Experimental Therapeutics newsletter|American Society for Pharmacology and Experimental Therapeutics#Publications{{!}}The Pharmacologist}}
...
46 KB (5,967 words) - 12:23, 15 November 2023
{{Redirect/ja|Pharmaceutical/ja||Pharmacy/ja|と|Pharmacology/ja|と|Pharmaceutical industry/ja}}
薬物治療（[[pharmacotherapy/ja|薬物療法]]）は[[medicine/ja|医療分野]]の重要な一部であり、継続的な進歩のために[[pharmacology/ja|薬学]]の科学に、適切な管理のために[[pharmacy/ja|薬局]]に依存するものである。
...
58 KB (1,845 words) - 17:09, 5 November 2023
...acid derivatives. S-8307 and S-8308 have moderate [[Potency (pharmacology)|potency]], short duration of action and limited oral bioavailability, however they
...of the ARBs have the same [[mechanism of action]] and differences in their potency can be related to their different [[pharmacokinetic]] profiles. A few clini
...
22 KB (3,315 words) - 10:25, 28 March 2024
...tries, specifies the date up to which the manufacturer guarantees the full potency and safety of a drug. In the United States, expiration dates are determined
...ief, said that with a handful of exceptions—notably [[Glyceryl trinitrate (pharmacology)|nitroglycerin]], [[insulin]], some liquid antibiotics; outdated [[tetracyc
...
32 KB (4,423 words) - 10:32, 3 January 2023
In the fields of medicine, [[biotechnology]] and [[pharmacology]], '''drug discovery''' is the process by which new candidate [[pharmaceuti
...h are hypothesized to be disease-modifying in a process known as [[reverse pharmacology]]. Hits from these screens are then tested in cells and then in animals for
...
55 KB (7,244 words) - 08:05, 4 January 2023
{{Redirect|Pharmaceutical||Pharmacy|and|Pharmacology|and|Pharmaceutical industry}}
...the [[medicine|medical field]] and relies on the science of [[pharmacology|pharmacology]] for continual advancement and on [[pharmacy|pharmacy]] for appropriate ma
...
52 KB (6,923 words) - 17:09, 5 November 2023
{{Redirect|Pharmaceutical||Pharmacy|and|Pharmacology|and|Pharmaceutical industry}}
...the [[medicine|medical field]] and relies on the science of [[pharmacology|pharmacology]] for continual advancement and on [[pharmacy|pharmacy]] for appropriate ma
...
54 KB (7,245 words) - 17:08, 5 November 2023
...ch are a basis of [[traditional medicine]]. With worldwide research into [[pharmacology]], some herbal medicines have been translated into modern remedies, such as
...ng agents. Phytotherapy differs from plant-derived medicines in standard [[pharmacology]] because it does not isolate and [[Standardization|standardize]] the compo
...
26 KB (3,762 words) - 10:21, 17 March 2024
...ch are a basis of [[traditional medicine]]. With worldwide research into [[pharmacology]], some herbal medicines have been translated into modern remedies, such as
...ng agents. Phytotherapy differs from plant-derived medicines in standard [[pharmacology]] because it does not isolate and [[Standardization|standardize]] the compo
...
26 KB (3,876 words) - 10:21, 17 March 2024
...e Middle Ages: Principles that presage the 21st century | journal=Clinical Pharmacology & Therapeutics |volume=67 |issue=5|pages=447–450 [448–449] |pmid=10824622|s
...dverse reactions and challenges in monitoring safety |journal=Frontiers in Pharmacology |date=2013 |volume=4 |issue=3 |pages=202–4|doi=10.3389/fphar.2013.00177 |pm
...
72 KB (9,763 words) - 10:14, 3 January 2023
...clinical stability and process optimization as well as therapeutic product potency, [[bioavailability]] and [[immunogenicity]]. The generally accepted purific
...ry !! [[infliximab]]<ref name=Rang>{{cite book | vauthors = Rang HP |title=Pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2003 |pages=241,
...
44 KB (5,708 words) - 17:44, 3 January 2023
...structure of chemical substances, and growth in the emerging science of [[pharmacology]] expanded their ability to evaluate the biological effects of these struct
...in 1904. Systematic investigations of the effect of structural changes on potency and duration of action led to the discovery of [[phenobarbital]] at Bayer i
...
60 KB (8,551 words) - 22:13, 8 January 2023
...formulations (40 units per milliliter), so the effort to "standardize" the potency aimed to reduce dosage errors and ease doctors' job of prescribing insulin
...iated SI) which is the modern form of the [[metric system]]. Instead the [[Pharmacology|pharmacological]] [[International units|international unit]] (IU) is define
...
57 KB (8,343 words) - 13:17, 21 March 2024
...formulations (40 units per milliliter), so the effort to "standardize" the potency aimed to reduce dosage errors and ease doctors' job of prescribing insulin
...iated SI) which is the modern form of the [[metric system]]. Instead the [[Pharmacology|pharmacological]] [[International units|international unit]] (IU) is define
...
58 KB (8,527 words) - 13:16, 21 March 2024