フェブキソスタットにはヒトにおいて3つの活性代謝物があり、それらは主に多くの[[cytochrome P450/ja|チトクロームP450]]肝酵素（[[CYP1A1/ja|CYP1A1]]、[[CYP1A2/ja|1A2]]、[[CYP2C8/ja|2C8]]
[[Category:Xanthine oxidase inhibitors]]
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11 KB (519 words) - 20:40, 22 April 2024
...f some drugs as [[substrate (chemistry)|substrates]] or [[enzyme inhibitor|inhibitors]] of enzymes involved in xenobiotic metabolism are a common reason for haza
...ism is divided into three phases. In phase I, enzymes such as [[cytochrome P450 oxidase]]s introduce reactive or polar groups into xenobiotics. These modif
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29 KB (3,729 words) - 12:12, 15 November 2023
...readily excreted. In almost all of the transformations that they catalyze, P450's affect [[hydroxylation]].
P450 enzymes have been identified in all [[kingdom (biology)|kingdom]]s of life:
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38 KB (5,401 words) - 20:37, 15 March 2024
...readily excreted. In almost all of the transformations that they catalyze, P450's affect [[hydroxylation]].
P450 enzymes have been identified in all [[kingdom (biology)|kingdom]]s of life:
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39 KB (5,513 words) - 20:35, 15 March 2024
SGLT-2阻害薬、[[Glucagon-like peptide-1 receptor agonist/ja|GLP-1作動薬]]、および[[DPP-4 inhibitors/ja|DPP-4阻害薬]]を比較した[[systematic review/ja|システマティックレビュー]]と[[network meta-anal
...る場合は、低血糖を避けるために抗糖尿病薬の用量を調節することが重要である。例えば、スルホニル尿素との相互作用により、おそらく[[cytochrome P450/ja|チトクロームP450]]に起因すると思われる重篤な低血糖が起こっている。
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25 KB (941 words) - 09:18, 13 February 2024
1970年代後半に[[angiotensin converting enzyme inhibitors/ja|アンジオテンシン変換酵素（ACE）阻害薬]]が登場したことで、AngⅡが血圧や[[electrolyte/ja|電解質]]・体液バランスの調節に
ARBは[[renin–angiotensin system/ja|レニン-アンジオテンシン経路]]の最後の部分を遮断し、[[ACE inhibitors/ja|ACE阻害薬]]よりも特異的に経路を遮断する。
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27 KB (998 words) - 12:39, 28 March 2024
...ey act by inhibiting [[sodium-glucose transport protein 2]] (SGLT2). SGLT2 inhibitors are used in the treatment of [[type 2 diabetes]]. Apart from blood sugar co
...etes Association|ADA]] standards of medical care in diabetes include SGLT2 inhibitors as a first line [[pharmacological therapy]] for type 2 diabetes (usually to
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21 KB (2,807 words) - 19:46, 12 February 2024
...ey act by inhibiting [[sodium-glucose transport protein 2]] (SGLT2). SGLT2 inhibitors are used in the treatment of [[type 2 diabetes]]. Apart from blood sugar co
...etes Association|ADA]] standards of medical care in diabetes include SGLT2 inhibitors as a first line [[pharmacological therapy]] for type 2 diabetes (usually to
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21 KB (2,899 words) - 19:46, 12 February 2024
...sartan/ja|テルミサルタン]]などがある。これらはすべて同じ作用機序を持ち、[[lisinopril/ja|リシノプリル]]などの[[ACE inhibitors/ja|ACE阻害薬]]よりもアンジオテンシンの作用を阻害する可能性がある。
代謝は主に[[cytochrome P450/ja|チトクロームP450]]によって行われる。[[isoenzyme/ja|アイソザイム]]の[[CYP2C9/ja|CYP2C9]]および[[CY
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16 KB (932 words) - 15:52, 15 March 2024
...metabolites in humans, which are formed mainly by a number of [[cytochrome P450]] liver enzymes ([[CYP1A1]], [[CYP1A2|1A2]], [[CYP2C8|2C8]], [[CYP2C9|2C9]]
[[Category:Xanthine oxidase inhibitors]]
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9 KB (1,260 words) - 20:24, 22 April 2024
...metabolites in humans, which are formed mainly by a number of [[cytochrome P450]] liver enzymes ([[CYP1A1]], [[CYP1A2|1A2]], [[CYP2C8|2C8]], [[CYP2C9|2C9]]
[[Category:Xanthine oxidase inhibitors]]
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9 KB (1,308 words) - 20:19, 22 April 2024
...ar to Ang II and they bind to [[Angiotensin receptor|Ang II receptors]] as inhibitors, e.g., [T24 from Rhys Healthcare].
...giotensin converting enzyme inhibitors|angiotensin converting enzyme (ACE) inhibitors]] in the late 1970s it was confirmed that Ang II plays an important role in
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22 KB (3,221 words) - 10:25, 28 March 2024
...ar to Ang II and they bind to [[Angiotensin receptor|Ang II receptors]] as inhibitors, e.g., [T24 from Rhys Healthcare].
...giotensin converting enzyme inhibitors|angiotensin converting enzyme (ACE) inhibitors]] in the late 1970s it was confirmed that Ang II plays an important role in
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22 KB (3,315 words) - 10:25, 28 March 2024
...ction and potentially inhibit the actions of angiotensin better than [[ACE inhibitors]], such as [[lisinopril]], because there are other enzymes than ACE that ha
Metabolism is primarily by [[cytochrome P450]] [[isoenzyme]]s [[CYP2C9]] and [[CYP3A4]]. Peak plasma concentrations of l
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14 KB (1,889 words) - 22:47, 14 March 2024
...ction and potentially inhibit the actions of angiotensin better than [[ACE inhibitors]], such as [[lisinopril]], because there are other enzymes than ACE that ha
Metabolism is primarily by [[cytochrome P450]] [[isoenzyme]]s [[CYP2C9]] and [[CYP3A4]]. Peak plasma concentrations of l
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14 KB (1,957 words) - 22:46, 14 March 2024
ナイアシン[[Enzyme inhibitor/ja|阻害]][[cytochrome P450|シトクロムP450]]酵素[[CYP2E1/ja|CYP2E1]]、[[CYP2D6/ja|CYP2D6]]および[[CYP3A4/ja|CYP3A4
[[Category:CYP2D6 inhibitors]]
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55 KB (2,081 words) - 15:30, 20 February 2024
...|COX-2]]の酵素を阻害する。他の酵素阻害剤は毒である。例えば、毒[[cyanide/ja|シアン化合物]]は不可逆的な酵素阻害剤であり、酵素[[cytochrome c oxidase/ja|シトクロムcオキシダーゼ]]の活性部位にある銅と鉄と結合し、[[cellular respiration/ja|細胞呼吸]]
...]と呼ばれる酵素が誘導されるからである。もう1つの例は、[[drug metabolism/ja|薬物代謝]]において重要な[[cytochrome P450 oxidase/ja|シトクロムP450オキシダーゼ]]と呼ばれる[[liver/ja|肝臓]]の酵素である。これらの酵素の誘導や阻害は[[drug
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64 KB (2,204 words) - 15:33, 22 February 2024
...t increase activity. Many therapeutic [[drug]]s and [[poison]]s are enzyme inhibitors. An enzyme's activity decreases markedly outside its optimal [[temperature]
Enzyme reaction rates can be decreased by various types of enzyme inhibitors.
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52 KB (7,533 words) - 19:19, 21 February 2024
...t increase activity. Many therapeutic [[drug]]s and [[poison]]s are enzyme inhibitors. An enzyme's activity decreases markedly outside its optimal [[temperature]
Enzyme reaction rates can be decreased by various types of enzyme inhibitors.
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54 KB (7,773 words) - 19:18, 21 February 2024
...ter, releasing oxygen as a waste product. The electrons then flow to the [[cytochrome b6f complex]], which uses their energy to pump protons across the [[thylako
...etabolizing enzymes. In humans, these include [[cytochrome P450|cytochrome P450 oxidases]], [[Glucuronosyltransferase|UDP-glucuronosyltransferases]], and [
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54 KB (7,765 words) - 19:27, 22 January 2024