Translations:Vitamin D/97/en

Mechanism of action

Metabolic activation

Liver hydroxylation of cholecalciferol to calcifediol

Kidney hydroxylation of calcifediol to calcitriol

Vitamin D is carried via the blood to the liver, where it is converted into the prohormone calcifediol. Circulating calcifediol may then be converted into calcitriol – the biologically active form of vitamin D – in the kidneys.