Translations:Lipid-lowering agent/7/en

Research

Investigational classes of hypolipidemic agents:

• CETP inhibitors (cholesteryl ester transfer protein), 1 candidate is in trials. (Anacetrapib) It is expected that these drugs will mainly increase HDL while lowering LDL
• Squalene synthase inhibitor
• ApoA-1 Milano
• Succinobucol (AGI-1067), a novel antioxidant, failed a phase-III trial.
• Apoprotein-B inhibitor mipomersen (approved by the FDA in 2013 homozygous familial hypercholesterolemia.).
• Bempedoic acid, an ATP citrate lyase inhibitor