Translations:Insulin (medication)/17/en

Principles

The idealised diagram shows the fluctuation of blood sugar (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day containing three meals. In addition, the effect of a sugar-rich versus a starch-rich meal is highlighted.

Amino Acid Sequence of Insulin Preparations
Amino Acid Substitutions
	A-Chain Position			B-Chain Position
Source Species	A-8	A-10	A-21	B-28	B-29	B-30	B-31 B-32
Bovine	Ala	Val	Asn	Pro	Lys	Ala	N/A
Porcine	Thr	Ile	Asn	Pro	Lys	Ala	N/A
Human	Thr	Ile	Asn	Pro	Lys	Thr	N/A
Aspart (Novolog)	Thr	Ile	Asn	Asp	Lys	Thr	N/A
Lispro (Humalog)	Thr	Ile	Asn	Lys	Pro	Thr	N/A
Glulisine (Apidra)	Thr	Ile	Asn	Pro	Glu	Thr	N/A
Glargine (Lantus)	Thr	Ilc	Gly	Pro	Lys	Thr	Arg
Detemir(Levemir)	Thr	Ile	Asn	Pro	Lys	N/A	Myristic acid
Degludec(Tresiba)	Thr	Ile	Asn	Pro	Lys	N/A	Hexadecanedioic acid
Ala=Alanine Val=Valine Asn=Asparagine Pro=Proline Lys=Lysine Thr=Threonine Ile=Isoleucine Glu=Glutamine Gly=Glycine