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Discovery and development of gliflozins/29/en
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R
IC
50
(nM)
Activity
0.720
in vitro
activity improved*
1.14
in vitro
activity improved*
13.3
As the number of carbons increases, the IC-50 value fluctuates
19.6
in vitro
activity decreased*
21.2
in vitro
activity decreased*
*comparator to ethyl group (IC
50
= 16,7)