process of bringing a new pharmaceutical drug to the market once a lead compound has been identified
4 statements, 0 sitelinks - 21:37, 3 June 2023
...sure]]. The gliflozins canagliflozin, dapagliflozin, and empagliflozin may lead to euglycemic [[ketoacidosis]]. Other side effects of gliflozins include in
...authors = Calado J, Soto K, Clemente C, Correia P, Rueff J | title = Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive re
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5 KB (601 words) - 19:48, 18 February 2024
...sure]]. The gliflozins canagliflozin, dapagliflozin, and empagliflozin may lead to euglycemic [[ketoacidosis]]. Other side effects of gliflozins include in
...authors = Calado J, Soto K, Clemente C, Correia P, Rueff J | title = Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive re
...
5 KB (625 words) - 19:48, 18 February 2024
[[Phlorizin]] is a compound that has been known for over a century. It is a naturally occurring botanic
...inhibitor of facilitative [[glucose transporters]] and phlorizin seems to lead to serious adverse events in the gastrointestinal tract like [[diarrhea]] a
...
17 KB (2,477 words) - 09:56, 14 February 2024
...]（または[[prodrug/ja|プロドラッグ]]）である。[[testosterone/ja|テストステロン]]あるいは、[[synthetic compound/ja|合成]] AASのプロホルモン、例えば、[[nandrolone/ja|ナンドロロン]] （19 ノルテストステロン）ができる。[[Dehydr
...は、テストされたいくつかのプロテインパウダーから、安全でないレベルの[[arsenic/ja|ヒ素]]、[[cadmium/ja|カドミウム]]、[[lead/ja|鉛]]、[[Mercury (element)/ja|水銀]]が検出されたことを報告した。
...
16 KB (375 words) - 15:30, 27 October 2023
[[Phlorizin]] is a compound that has been known for over a century. It is a naturally occurring botanic
...inhibitor of facilitative [[glucose transporters]] and phlorizin seems to lead to serious adverse events in the gastrointestinal tract like [[diarrhea]] a
...
17 KB (2,553 words) - 09:56, 14 February 2024
...f name=Bender>{{Cite journal | last =Bender | first =A | title =Databases: Compound bioactivities go public | journal =[[Nature Chemical Biology]] | volume =6
The ChEMBL database contains compound bioactivity data against drug targets. Bioactivity is reported in Ki, Kd, I
...
9 KB (1,167 words) - 12:45, 15 November 2023
** COMPOUND, GLYCAN: [[chemical compound]]s and [[glycan]]s
...Alternatively, a set of [[metabolite]]s identified in the metabolome will lead to the understanding of enzymatic pathways and enzyme genes involved.
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15 KB (1,996 words) - 13:53, 14 November 2023
...ools to probe [[function (biology)|biological function]] as well as [[lead compound|leads]] in the development of new [[pharmaceutical drug|therapeutic agents]
...kept below this limit.<ref>{{cite journal | author = Lipinski CA | title = Lead-and drug-like compounds: the rule-of-five revolution | journal = Drug Disco
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11 KB (1,440 words) - 16:29, 3 January 2023
...ad to increased blood pressure. By blocking AT<sub>1</sub> receptors, ARBs lead to lower blood pressure.
...leads were bound at the same receptor site. These two substances served as lead compounds for further optimization of AT<sub>1</sub> receptor blockers.
...
22 KB (3,221 words) - 10:25, 28 March 2024
...ad to increased blood pressure. By blocking AT<sub>1</sub> receptors, ARBs lead to lower blood pressure.
...leads were bound at the same receptor site. These two substances served as lead compounds for further optimization of AT<sub>1</sub> receptor blockers.
...
22 KB (3,315 words) - 10:25, 28 March 2024
...des experience no symptoms. Some forms of primary hypertriglyceridemia can lead to specific symptoms: both familial chylomicronemia and primary [[Combined
The word ''hypertriglyceridemia'' uses [[classical compound|combining forms]] of ''[[wikt:hyper-#Prefix|hyper-]]'' + ''[[triglyceride]]
...
8 KB (925 words) - 22:26, 15 April 2024
...ess]], mental confusion, and [[diarrhea]]. In advanced cases, pellagra may lead to [[dementia]] and death (the 3(+1) D's: dermatitis, diarrhea, dementia, a
...s. [[Multiple carboxylase deficiency]], an inborn error of metabolism, can lead to biotin deficiency even when dietary biotin intake is normal.
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22 KB (3,101 words) - 08:50, 18 February 2024
...ess]], mental confusion, and [[diarrhea]]. In advanced cases, pellagra may lead to [[dementia]] and death (the 3(+1) D's: dermatitis, diarrhea, dementia, a
...s. [[Multiple carboxylase deficiency]], an inborn error of metabolism, can lead to biotin deficiency even when dietary biotin intake is normal.
...
22 KB (3,143 words) - 08:50, 18 February 2024
...des experience no symptoms. Some forms of primary hypertriglyceridemia can lead to specific symptoms: both familial chylomicronemia and primary [[Combined
The word ''hypertriglyceridemia'' uses [[classical compound|combining forms]] of ''[[wikt:hyper-#Prefix|hyper-]]'' + ''[[triglyceride]]
...
8 KB (969 words) - 22:24, 15 April 2024
...oordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been
A lack of cobalamin can lead to [[megaloblastic anemia]] and subacute combined degeneration of the spina
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6 KB (779 words) - 13:59, 7 April 2024
...oordination chemistry]], methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. [[Nickel]]–methyl intermediates have been
A lack of cobalamin can lead to [[megaloblastic anemia]] and subacute combined degeneration of the spina
...
6 KB (813 words) - 13:57, 7 April 2024
...omplications]]. Combined Metformin and Sulphonylurea therapy did appear to lead to higher risk of [[Hypoglycemia]].
...tment of [[Latent autoimmune diabetes in adults|LADA]] using sulfonylureas lead to earlier insulin dependence in approximately 30% of cases.
...
12 KB (1,572 words) - 20:36, 12 March 2024
...omplications]]. Combined Metformin and Sulphonylurea therapy did appear to lead to higher risk of [[Hypoglycemia]].
...tment of [[Latent autoimmune diabetes in adults|LADA]] using sulfonylureas lead to earlier insulin dependence in approximately 30% of cases.
...
12 KB (1,638 words) - 20:35, 12 March 2024
...994 DSHEA further consolidated the position of the supplement industry and lead to additional product sales.
...oid]] (AAS). They can be prohormones of [[testosterone]] or of [[synthetic compound|synthetic]] AAS, for example, [[nandrolone]] (19-nortestosterone). [[Dehydr
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12 KB (1,685 words) - 08:24, 24 October 2023