Translations:Folate/50/en

Increased homocysteine levels suggest tissue folate deficiency, but homocysteine is also affected by vitamin B₁₂ and vitamin B₆, renal function, and genetics. One way to differentiate between folate deficiency and vitamin B₁₂ deficiency is by testing for methylmalonic acid (MMA) levels. Normal MMA levels indicate folate deficiency and elevated MMA levels indicate vitamin B₁₂ deficiency. Elevated MMA levels may also be due to the rare metabolic disorder combined malonic and methylmalonic aciduria (CMAMMA).