Translations:Angiotensin II receptor blocker/35/en

Research

Longevity

Knockout of the Agtr1a gene that encodes AT₁ results in marked prolongation of the life-span of mice, by 26% compared to controls. The likely mechanism is reduction of oxidative damage (especially to mitochondria) and overexpression of renal prosurvival genes. The ARBs seem to have the same effect.