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 h English (en)The pyrimidine ring system is formed in a reaction catalysed by [[phosphomethylpyrimidine synthase]] (ThiC), an enzyme in the [[radical SAM]] superfamily of [[iron–sulfur protein]]s, which use [[S-adenosyl methionine]] as a [[Cofactor (biochemistry)|cofactor]].
:[[File:Pyrimidine biosynthesis.svg|650px]]
 h Japanese (ja)ピリミジン環系は、[[S-adenosyl methionine/ja|S-アデノシルメチオニン]]を[[Cofactor (biochemistry)/ja|補酵素]]として用いる[[iron–sulfur protein/ja|鉄-硫黄タンパク質]]の[[radical SAM/ja|ラジカルSAM]]スーパーファミリーの酵素である[[phosphomethylpyrimidine synthase/ja|ホスホメチルピリミジン合成酵素]](ThiC)によって触媒される反応で形成される。
:[[File:Pyrimidine biosynthesis.svg|450px]]