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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | ==Mechanism of action== Vitamin B<sub>12</sub> refers to a group of compounds called cobalamins that are available in the human body in a variety of mostly interconvertible forms. Together with [[folate]], cobalamins are essential cofactors required for [[DNA]] synthesis in cells where [[chromosomal]] replication and division are occurring—most notably the [[bone marrow]] and [[myeloid]] cells. As a [[Cofactor (biochemistry)|cofactor]], cobalamins are essential for two cellular reactions: *the mitochondrial [[methylmalonyl-CoA mutase]] conversion of [[methylmalonic acid]] (MMA) to [[succinate]], which links lipid and carbohydrate metabolism, and *the activation of [[methionine synthase]], which is the rate-limiting step in the synthesis of [[methionine]] from [[homocysteine]] and [[5-methyltetrahydrofolate]]. |
| h Japanese (ja) | ==作用機序== {{Anchor|Mechanism of action}} ビタミンB<sub>12</sub>はコバラミンと呼ばれる化合物群を指し、人体内では様々な相互変換可能な形で存在する。コバラミンは[[folate/ja|葉酸]]とともに、[[chromosomal/ja|染色体]]の複製と分裂が起こる細胞、特に[[bone marrow/ja|骨髄]]と[[myeloid/ja|骨髄系]]細胞において、[[DNA/ja|DNA]]の合成に必要な必須補因子である。[[Cofactor (biochemistry)/ja|補因子]]として、コバラミンは2つの細胞反応に必須である： *ミトコンドリアの[[methylmalonyl-CoA mutase/ja|メチルマロニル-CoAミューターゼ]]による[[methylmalonic acid/ja|メチルマロン酸]]（MMA）の[[succinate/ja|コハク酸]]への変換である。 *[[homocysteine/ja|ホモシステイン]]と[[5-methyltetrahydrofolate/ja|5-メチルテトラヒドロ葉酸]]から[[methionine/ja|メチオニン]]を合成する際の律速段階である[[methionine synthase/ja|メチオニン合成酵素]]の活性化である。 |