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 h English (en)GLP-1 is packaged in secretory granules and secreted into the [[hepatic portal system]] by the intestinal L-cells located primarily in the distal [[ileum]] and colon, but also found in the [[jejunum]] and [[duodenum]]. The L-cells are open-type triangular [[epithelial cells]] directly in contact with the [[Lumen (anatomy)|lumen]] and neuro-vascular tissue and are accordingly stimulated by various [[nutrient]], [[neural]] and [[endocrine]] factors.
 h Japanese (ja)GLP-1は分泌顆粒にパッケージされ、主に[[ileum/ja|回腸]]と結腸の遠位に位置するが、[[jejunum/ja|空腸]]と[[duodenum/ja|十二指腸]]にも存在する腸管L細胞によって[[hepatic portal system/ja|肝門脈系]]に分泌される。L細胞は開口型の三角形の[[epithelial cells/ja|上皮細胞]]で、[[Lumen (anatomy)/ja|内腔]]や神経血管組織と直接接しており、それに応じて様々な[[nutrient/ja|栄養]]、[[neural/ja|神経]]、[[endocrine/ja|内分泌]]因子によって刺激される。