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Found 2 translations.
Name | Current message text |
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h English (en) | The [[pyrrolidine]] type of [[DPP-4 inhibitor]]s was first discovered after [[High throughput screening|HTS]]. Research showed that the [[pyrrolidine]] rings were the part of the compounds that fit into the [[binding site]]. Further development has led to [[fluoro]] substituted pyrrolidines that show superior activity, as well as [[pyrrolidine]]s with fused cyclopropylrings that are highly active. |
h Japanese (ja) | [[pyrrolidine/ja|ピロリジン]]型の[[DPP-4 inhibitor/ja|DPP-4阻害剤]]は、[[High throughput screening/ja|HTS]]の後に初めて発見された。研究により、[[pyrrolidine/ja|ピロリジン]]環が化合物の[[binding site/ja|結合部位]]に適合する部分であることが示された。さらに開発が進められ、優れた活性を示す[[fluoro/ja|フルオロ]]置換ピロリジンや、高い活性を示す縮合シクロプロピル環を持つ[[pyrrolidine/ja|ピロリジン]]が開発された。 |