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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | Using [[nuclear magnetic resonance]] studies on the spatial structure of Ang II, scientists at DuPont discovered that the Takeda structures had to be enlarged at a particular position to resemble more closely the much larger peptide Ang II. Computer modeling was used to compare S-8308 and S-8307 with Ang II and it was seen that Ang II contains two [[acidic]] residues near the NH<sub>2</sub> terminus. These groups were not mimicked by the Takeda leads and therefore it was hypothesized that acidic [[functional groups]] would have to be added to the compounds.<br /> The 4-carboxy-derivative EXP-6155 had a binding activity which was ten-fold greater than that of S-8308 which further strengthened this [[hypothesis]]. |
| h Japanese (ja) | DuPontの科学者たちは、Ang IIの空間構造に関する[[nuclear magnetic resonance/ja|核磁気共鳴]]研究を用いて、武田薬品の構造体が、より大きなペプチドAng IIにより近くなるように特定の位置を拡大しなければならないことを発見した。 コンピュータ・モデリングを使ってS-8308とS-8307をAng IIと比較したところ、Ang IIにはNH<sub>2</sub>末端付近に2つの[[acidic/ja|酸性]]残基があることがわかった。これらの基は武田薬品のリード化合物では模倣されなかったため、酸性[[functional groups/ja|官能基]]を化合物に付加する必要があるという仮説が立てられた<br />。 4-カルボキシ誘導体であるEXP-6155はS-8308の10倍以上の結合活性を示し、この[[hypothesis/ja|仮説]]はさらに強固なものとなった。 |