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 h English (en)DPP-4 is known to cleave a broad range of [[Substrate (biochemistry)|substrates]] including [[growth factor]]s, [[chemokine]]s, [[neuropeptide]]s, and [[vasoactive]] peptides. The cleaved substrates lose their biological activity in the majority of cases, but in the case of the chemokine RANTES and neuropeptide Y, DPP-4 mediated cleavage leads to a shift in the receptor subtype binding.
 h Japanese (ja)DPP-4は[[growth factor/ja|成長因子]]、[[chemokine/ja|ケモカイン]]、[[neuropeptide/ja|神経ペプチド]]、[[vasoactive/ja|血管作動性]]ペプチドを含む広範囲の[[Substrate (biochemistry)/ja|基質]]を切断することが知られている。ほとんどの場合、切断された基質は生物学的活性を失うが、ケモカインのRANTESと神経ペプチドYの場合、DPP-4を介した切断は受容体のサブタイプ結合のシフトをもたらす。