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Found 2 translations.
| Name | Current message text |
|---|---|
| h English (en) | P450s have been extensively examined in [[mice]], [[rat]]s, [[dog]]s, and less so in [[zebrafish]], in order to facilitate use of these [[model organisms]] in [[drug discovery]] and [[toxicology]]. Recently P450s have also been discovered in avian species, in particular turkeys, that may turn out to be a useful model for cancer research in humans. [[CYP1A5]] and [[CYP3A37]] in turkeys were found to be very similar to the human [[CYP1A2]] and [[CYP3A4]] respectively, in terms of their kinetic properties as well as in the metabolism of aflatoxin B1. |
| h Japanese (ja) | P450は[[mice/ja|マウス]]、[[rat/ja|ラット]]、[[dog/ja|イヌ]]で広く調べられてきたが、[[zebrafish/ja|ゼブラフィッシュ]]ではあまり調べられてこなかった。最近では、鳥類、特に七面鳥でもP450が発見されており、ヒトのがん研究の有用なモデルになるかもしれない。七面鳥の[[CYP1A5/ja|CYP1A5]]と[[CYP3A37/ja|CYP3A37]]は、それぞれヒトの[[CYP1A2/ja|CYP1A2]]と[[CYP3A4/ja|CYP3A4]]に速度論的特性やアフラトキシンB1の代謝において非常に類似していることが判明した。 |