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 h English (en)===Sporulation===
{{main|Sporulation in Bacillus subtilis}}
{{further|Sporulation}}
{{excerpt|Sporulation in Bacillus subtilis|Commitment to sporulation}}Once ''B. subtilis'' commits to sporulation, the [[sigma factor]] sigma F is secreted. This factor promotes sporulation. A sporulation septum is formed and a chromosome is slowly moved into the forespore. When a third of one chromosome copy is in the forespore and the remaining two thirds is in the mother cell, the chromosome fragment in the forespore contains the locus for sigma F, which begins to be expressed in the forespore. In order to prevent sigma F expression in the mother cell, an anti-sigma factor, which is encoded by spoIIAB, is expressed. Any residual anti-sigma factor in the forespore (which would otherwise interfere with sporulation) is inhibited by an anti-anti-sigma factor, which is encoded by spoIIAA. SpoIIAA is located near the locus for the sigma factor, so it is consistently expressed in the forespore. Since the spoIIAB locus is not located near the sigma F and spoIIAA loci, it is expressed only in the mother cell and therefore repress sporulation in that cell, allowing sporulation to continue in the forespore. Residual spoIIAA in the mother cell represses spoIIAB, but spoIIAB is constantly replaced so it continues to inhibit sporulation. When the full chromosome localizes to the forespore, spoIIAB can repress sigma F. Therefore, the genetic asymmetry of the ''B. subtilis'' chromosome and expression of sigma F, spoIIAB and spoIIAA dictate spore formation in ''B. subtilis.'' 
[[File:B._subtilis_sporulation_reg.png|thumb|Regulation of sporulation in B. subtilis]]
{{excerpt|Sporulation in Bacillus subtilis|Nature of regulation|hat=no}}
 h Japanese (ja)===胞子形成===
{{main/ja|Sporulation in Bacillus subtilis/ja}}
{{further/ja|Sporulation/ja}}
{{excerpt|Sporulation in Bacillus subtilis/ja|胞子形成へのコミットメント}}
''枯草菌''が胞子形成に入ると、[[sigma factor/ja|シグマ因子]]シグマFが分泌される。この因子は胞子形成を促進する。胞子形成隔壁が形成され、染色体が前胞子の中にゆっくりと移動する。染色体の1コピーの3分の1が前胞体にあり、残りの3分の2が母細胞にあるとき、前胞体の染色体断片にはシグマFの遺伝子座があり、前胞体で発現が始まる。母細胞でのシグマFの発現を防ぐために、spoIIABがコードするアンチシグマ因子が発現する。前胞子に残存するアンチシグマ因子(そうでなければ胞子形成を阻害する)は、spoIIAAによってコードされるアンチシグマ因子によって阻害される。SpoIIAAはシグマ因子の遺伝子座の近くに位置するため、前胞子で常に発現している。spoIIAB遺伝子座はシグマF遺伝子座とspoIIAA遺伝子座の近くにはないので、母細胞でのみ発現し、その細胞での胞子形成を抑制し、前胞子での胞子形成を継続させる。母細胞に残存するspoIIAAはspoIIABを抑制するが、spoIIABは常に置換されるため、胞子形成を抑制し続ける。したがって、''枯草菌''の染色体の遺伝的非対称性とシグマF、spoIIAB、spoIIAAの発現が、''枯草菌''の胞子形成を決定している。
[[File:B._subtilis_sporulation_reg.png|thumb|枯草菌における胞子形成の制御]]
{{excerpt|Sporulation in Bacillus subtilis/ja|調節の性質|hat=no}}