Translations:Cholecalciferol/27/en: Difference between revisions

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Message definition (Cholecalciferol)
The three steps in the synthesis and activation of vitamin D<sub>3</sub> are regulated as follows:
* Cholecalciferol is synthesized in the skin from 7-dehydrocholesterol under the action of ultraviolet B (UVB) light. It reaches an equilibrium after several minutes depending on the intensity of the UVB in the sunlight – determined by latitude, season, cloud cover, and altitude – and the age and degree of pigmentation of the skin.
* Hydroxylation in the endoplasmic reticulum of liver [[hepatocyte]]s of cholecalciferol to calcifediol (25-hydroxycholecalciferol) by [[CYP2R1|25-hydroxylase]] is loosely regulated, if at all, and blood levels of this molecule largely reflect the amount of cholecalciferol produced in the skin combined with any vitamin D<sub>2</sub> or D<sub>3</sub> ingested.
* Hydroxylation in the kidneys of calcifediol to calcitriol by [[25-Hydroxyvitamin D3 1-alpha-hydroxylase|1-alpha-hydroxylase]] is tightly regulated: it is stimulated by [[parathyroid hormone]] and serves as the major control point in the production of the active circulating hormone [[calcitriol]] (1,25-dihydroxyvitamin D<sub>3</sub>).

The three steps in the synthesis and activation of vitamin D3 are regulated as follows:

  • Cholecalciferol is synthesized in the skin from 7-dehydrocholesterol under the action of ultraviolet B (UVB) light. It reaches an equilibrium after several minutes depending on the intensity of the UVB in the sunlight – determined by latitude, season, cloud cover, and altitude – and the age and degree of pigmentation of the skin.
  • Hydroxylation in the endoplasmic reticulum of liver hepatocytes of cholecalciferol to calcifediol (25-hydroxycholecalciferol) by 25-hydroxylase is loosely regulated, if at all, and blood levels of this molecule largely reflect the amount of cholecalciferol produced in the skin combined with any vitamin D2 or D3 ingested.
  • Hydroxylation in the kidneys of calcifediol to calcitriol by 1-alpha-hydroxylase is tightly regulated: it is stimulated by parathyroid hormone and serves as the major control point in the production of the active circulating hormone calcitriol (1,25-dihydroxyvitamin D3).
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