Translations:Folate/26/en: Difference between revisions

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Message definition (Folate)
Some evidence links a shortage of folate with [[clinical depression]]. Limited evidence from [[randomized controlled trials]] showed using folic acid in addition to [[selective serotonin reuptake inhibitor]]s (SSRIs) may have benefits. Research found a link between depression and low levels of folate. The exact mechanisms involved in the development of schizophrenia and depression are not entirely clear, but the bioactive folate, [[Levomefolic acid|methyltetrahydrofolate]] (5-MTHF), a direct target of methyl donors such as [[S-adenosyl methionine]] (SAMe), recycles the inactive [[dihydrobiopterin]] (BH<sub>2</sub>) into [[tetrahydrobiopterin]] (BH<sub>4</sub>), the necessary [[Cofactor (biochemistry)|cofactor]] in various steps of monoamine synthesis, including that of [[dopamine]] and [[serotonin]]. BH<sub>4</sub> serves a regulatory role in monoamine neurotransmission and is required to mediate the actions of most antidepressants.

Some evidence links a shortage of folate with clinical depression. Limited evidence from randomized controlled trials showed using folic acid in addition to selective serotonin reuptake inhibitors (SSRIs) may have benefits. Research found a link between depression and low levels of folate. The exact mechanisms involved in the development of schizophrenia and depression are not entirely clear, but the bioactive folate, methyltetrahydrofolate (5-MTHF), a direct target of methyl donors such as S-adenosyl methionine (SAMe), recycles the inactive dihydrobiopterin (BH2) into tetrahydrobiopterin (BH4), the necessary cofactor in various steps of monoamine synthesis, including that of dopamine and serotonin. BH4 serves a regulatory role in monoamine neurotransmission and is required to mediate the actions of most antidepressants.