Translations:Pyridoxal phosphate/28/en

Examples of inhibitors:

• Levothyroxine In rats given only 10 µg of D, L-thyroxine daily for 15 days, liver cysteine desulfhydrase activity disappears and serine and threonine dehydrase and alanine glutamate transaminase activities decrease about 40%. Either in vivo feeding of pyridoxal-5-phosphate or in vitro addition of the coenzyme to the liver preparations restores full activity to all these enzymes, and the slight in vitro inhibition in the presence of 10⁻⁵ M thyroxine is also reversed by pyridoxal-5-phosphate.
• The inactive form pyridoxine competitively inhibits the active pyridoxal-5'-phosphate. Consequently, symptoms of vitamin B6 supplementation in the pyridoxine form can mimic those of vitamin B6 deficiency; an effect which perhaps might be avoided by supplementing with P5P instead.
• AlaP (alanine phosphonate) inhibits alanine racemases, but its lack of specificity has prompted further designs of ALR inhibitors.
• Gabaculine and Vigabatrin inhibit GABA aminotransferase
• Canaline and 5-fluoromethylornithine inhibit ornithine aminotransferase
• Amino-oxy SAM inhibits ACC synthase