Translations:Vitamin B6/5/en: Difference between revisions

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Message definition (Vitamin B6)
===Forms===
Because of its chemical stability, pyridoxine hydrochloride is the form most commonly given as vitamin B<sub>6</sub> dietary supplement. Absorbed pyridoxine (PN) is converted to pyridoxamine 5'-phosphate (PMP) by the enzyme [[pyridoxal kinase]], with PMP further converted to pyridoxal 5'-phosphate (PLP), the metabolically active form, by the enzymes [[pyridoxamine-phosphate transaminase]] or [[pyridoxine 5'-phosphate oxidase]], the latter of which also catalyzes the conversion of pyridoxine 5′-phosphate (PNP) to PLP. Pyridoxine 5'-phosphate oxidase is dependent on [[flavin mononucleotide]] (FMN) as a cofactor produced from [[riboflavin]] (vitamin B<sub>2</sub>). For degradation, in a non-reversible reaction, PLP is [[Catabolism|catabolized]] to 4-pyridoxic acid, which is excreted in urine.

Forms

Because of its chemical stability, pyridoxine hydrochloride is the form most commonly given as vitamin B6 dietary supplement. Absorbed pyridoxine (PN) is converted to pyridoxamine 5'-phosphate (PMP) by the enzyme pyridoxal kinase, with PMP further converted to pyridoxal 5'-phosphate (PLP), the metabolically active form, by the enzymes pyridoxamine-phosphate transaminase or pyridoxine 5'-phosphate oxidase, the latter of which also catalyzes the conversion of pyridoxine 5′-phosphate (PNP) to PLP. Pyridoxine 5'-phosphate oxidase is dependent on flavin mononucleotide (FMN) as a cofactor produced from riboflavin (vitamin B2). For degradation, in a non-reversible reaction, PLP is catabolized to 4-pyridoxic acid, which is excreted in urine.