Translations:Sulfonylurea/24/en: Difference between revisions

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Message definition (Sulfonylurea)
Sulfonylureas bind to and close [[ATP-sensitive potassium channel|ATP-sensitive K<sup>+</sup>]] (K<sub>ATP</sub>) channels on the cell membrane of pancreatic [[beta cell]]s, which depolarizes the cell by preventing potassium from exiting. This [[depolarization]] opens voltage-gated [[calcium|Ca]]<sup>2+</sup> channels. The rise in intracellular calcium leads to increased fusion of [[insulin]] granules with the cell membrane, and therefore increased [[Insulin#Synthesis|secretion]] of mature insulin.

Sulfonylureas bind to and close ATP-sensitive K+ (KATP) channels on the cell membrane of pancreatic beta cells, which depolarizes the cell by preventing potassium from exiting. This depolarization opens voltage-gated Ca2+ channels. The rise in intracellular calcium leads to increased fusion of insulin granules with the cell membrane, and therefore increased secretion of mature insulin.

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