Translations:Glucagon-like peptide-1/8/en: Difference between revisions

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Message definition (Glucagon-like peptide-1)
In the gut and brain, [[proglucagon]] is catalysed by PC 1/3 giving rise to glicentin, which may be further processed to GRPP and [[oxyntomodulin]], GLP-1, intervening peptide-2 (IP-2) and [[glucagon-like peptide-2]] ([[GLP-2]]). Initially, GLP-1 was thought to correspond to proglucagon (72–108) suitable with the [[N-terminal]] of the MGPF, but sequencing experiments of endogenous GLP-1 revealed a structure corresponding to proglucagon (78–107) from which two discoveries were found. Firstly, the full-length GLP-1 (1–37) was found to be catalysed by [[endopeptidase]] to the biologically active GLP-1 (7–37). Secondly, the [[glycine]] corresponding to proglucagon(108) was found to serve as a substrate for [[amidation]] of the [[C-terminal]] [[arginine]] resulting in the equally potent GLP-1 (7–36) amide. In humans, almost all (>80%) secreted GLP-1 is amidated, whereas a considerable part remains GLP-1 (7–37) in other species.

In the gut and brain, proglucagon is catalysed by PC 1/3 giving rise to glicentin, which may be further processed to GRPP and oxyntomodulin, GLP-1, intervening peptide-2 (IP-2) and glucagon-like peptide-2 (GLP-2). Initially, GLP-1 was thought to correspond to proglucagon (72–108) suitable with the N-terminal of the MGPF, but sequencing experiments of endogenous GLP-1 revealed a structure corresponding to proglucagon (78–107) from which two discoveries were found. Firstly, the full-length GLP-1 (1–37) was found to be catalysed by endopeptidase to the biologically active GLP-1 (7–37). Secondly, the glycine corresponding to proglucagon(108) was found to serve as a substrate for amidation of the C-terminal arginine resulting in the equally potent GLP-1 (7–36) amide. In humans, almost all (>80%) secreted GLP-1 is amidated, whereas a considerable part remains GLP-1 (7–37) in other species.

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